LIN9_DANRE
ID LIN9_DANRE Reviewed; 543 AA.
AC Q5RHQ8;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein lin-9 homolog;
GN Name=lin9; ORFNames=si:dkey-206f10.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBUNIT: Component of the DREAM complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lin-9 family. {ECO:0000305}.
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DR EMBL; BX470188; CAI20899.1; -; Genomic_DNA.
DR RefSeq; NP_001038411.1; NM_001044946.1.
DR AlphaFoldDB; Q5RHQ8; -.
DR STRING; 7955.ENSDARP00000127210; -.
DR PaxDb; Q5RHQ8; -.
DR PRIDE; Q5RHQ8; -.
DR Ensembl; ENSDART00000152976; ENSDARP00000127210; ENSDARG00000028475.
DR GeneID; 560867; -.
DR KEGG; dre:560867; -.
DR CTD; 286826; -.
DR ZFIN; ZDB-GENE-030131-1747; lin9.
DR eggNOG; KOG1019; Eukaryota.
DR GeneTree; ENSGT00390000003188; -.
DR InParanoid; Q5RHQ8; -.
DR OrthoDB; 622946at2759; -.
DR PhylomeDB; Q5RHQ8; -.
DR TreeFam; TF314315; -.
DR Reactome; R-DRE-1538133; G0 and Early G1.
DR PRO; PR:Q5RHQ8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000028475; Expressed in testis and 28 other tissues.
DR ExpressionAtlas; Q5RHQ8; baseline.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0017053; C:transcription repressor complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR033471; DIRP.
DR InterPro; IPR010561; LIN-9/ALY1.
DR InterPro; IPR045831; LIN9_C.
DR PANTHER; PTHR21689; PTHR21689; 1.
DR Pfam; PF06584; DIRP; 1.
DR Pfam; PF19438; LIN9_C; 1.
DR SMART; SM01135; DIRP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..543
FT /note="Protein lin-9 homolog"
FT /id="PRO_0000249549"
FT REGION 21..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..451
FT /evidence="ECO:0000255"
FT COMPBIAS 21..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 61731 MW; 11AFFF951EAEC9E9 CRC64;
MAELEQLLDE SSSAKALVSL REGSLSNTLN EKNNLPKSQT TRGRSSYVSM ETPTRSSKRS
RLSCEDEERP IASRSPRRSQ RVTTMPQKLT NVATPDKRVS QKIGLRLRNL LKLPKAHKWC
IYEWFYSNID RPLFEGDNDF CLCLKESFPN LKTRKLTRVE WGTIRRLMGK PRRCSSAFFA
EERMALKQKR QKMRLLQQRK ITDMSLCKDL PDEIPLPLVI GTKVTARLRG VHDGLFTGQI
DAVDTSAATY RVTFDRNGLG THTVPDYEVL SNEPHETMPI SAFAQKQRPP RFQNFLTPPR
GSYTGSTQSI LMDNDPLFSQ SPWRSKLTGT DGETLGGFPV KFLVQVTRLS KILMIKKEHI
KHLKEMNTEA EKLKSYSMPI GLDLQKRYAT TVLDLEQLNK DLNKVLHEVQ QFCFELAPDQ
GMQPADQPSE LRRRCEEESQ DVLRQNNTLA SGEPRVQNTE LTQLISRLTA LLLQIRCLAE
GGDLNSFEFK SLTDSLNDIK SSIDDSNLSC FQDNVEIHVA HIQSGLSQLG NLHAFSANNT
NRT
