ID   LINA_STAHA              Reviewed;         161 AA.
AC   P06107;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Lincosamide resistance protein;
GN   Name=linA;
OS   Staphylococcus haemolyticus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3091456; DOI=10.1016/0378-1119(86)90213-1;
RA   Brisson-Noel A., Courvalin P.;
RT   "Nucleotide sequence of gene linA encoding resistance to lincosamides in
RT   Staphylococcus haemolyticus.";
RL   Gene 43:247-253(1986).
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DR   EMBL; M14039; AAA26652.1; -; Genomic_DNA.
DR   PIR; A25633; A25633.
DR   RefSeq; WP_063851340.1; NG_047913.1.
DR   PDB; 4FO1; X-ray; 2.15 A; A/B=1-161.
DR   PDB; 4WH5; X-ray; 1.82 A; A/B=2-161.
DR   PDBsum; 4FO1; -.
DR   PDBsum; 4WH5; -.
DR   AlphaFoldDB; P06107; -.
DR   SMR; P06107; -.
DR   KEGG; ag:AAA26652; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR019646; Aminoglyc_AdlTrfase.
DR   InterPro; IPR043519; NT_sf.
DR   Pfam; PF10706; Aminoglyc_resit; 1.
DR   SUPFAM; SSF81301; SSF81301; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic resistance.
FT   CHAIN           1..161
FT                   /note="Lincosamide resistance protein"
FT                   /id="PRO_0000068570"
FT   HELIX           8..21
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          25..28
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           29..37
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          45..52
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           53..55
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           56..65
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          69..74
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   TURN            75..77
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          78..83
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   TURN            84..86
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          87..96
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          102..105
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          109..114
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           116..118
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          119..124
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   STRAND          127..132
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           134..140
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           143..145
FT                   /evidence="ECO:0007829|PDB:4WH5"
FT   HELIX           148..158
FT                   /evidence="ECO:0007829|PDB:4WH5"
SQ   SEQUENCE   161 AA;  19041 MW;  A90B83A074B4753F CRC64;
     MKNNNVTEKE LFYILDLFEH MKVTYWLDGG WGVDVLTGKQ QREHRDIDID FDAQHTQKVI
     QKLEDIGYKI EVHWMPSRME LKHEEYGYLD IHPINLNDDG SITQANPEGG NYVFQNDWFS
     ETNYKDRKIP CISKEAQLLF HSGYDLTETD HFDIKNLKSI T