LINES_MOUSE
ID LINES_MOUSE Reviewed; 764 AA.
AC Q3U1D0; Q3TBL8; Q6PCP6; Q8K4P9;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein Lines homolog 1 {ECO:0000312|MGI:MGI:1919885};
DE AltName: Full=Protein Lines homolog 2 {ECO:0000305};
DE AltName: Full=Wnt-signaling molecule Lines homolog 1 {ECO:0000250|UniProtKB:Q8NG48};
GN Name=Lins1 {ECO:0000312|MGI:MGI:1919885};
GN Synonyms=Lins {ECO:0000305}, Lins2 {ECO:0000312|MGI:MGI:1919885},
GN Wins2 {ECO:0000312|MGI:MGI:1919885};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12119551;
RA Katoh M.;
RT "Molecular cloning and characterization of human WINS1 and mouse Wins2,
RT homologous to Drosophila segment polarity gene Lines (Lin).";
RL Int. J. Mol. Med. 10:155-159(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3U1D0-1; Sequence=Displayed;
CC Name=2; Synonyms=Wins2;
CC IsoId=Q3U1D0-2; Sequence=VSP_039707;
CC Name=3;
CC IsoId=Q3U1D0-3; Sequence=VSP_039708;
CC -!- SIMILARITY: Belongs to the protein lines family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59228.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH59228.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305};
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DR EMBL; AB083158; BAB93865.1; -; mRNA.
DR EMBL; AK171170; BAE42291.1; -; mRNA.
DR EMBL; AK156066; BAE33568.1; -; mRNA.
DR EMBL; BC059228; AAH59228.1; ALT_SEQ; mRNA.
DR EMBL; BC138549; AAI38550.1; -; mRNA.
DR CCDS; CCDS21348.2; -. [Q3U1D0-1]
DR CCDS; CCDS57555.1; -. [Q3U1D0-3]
DR RefSeq; NP_001177930.1; NM_001191001.1. [Q3U1D0-3]
DR RefSeq; NP_690028.2; NM_152815.2. [Q3U1D0-1]
DR RefSeq; XP_006541280.1; XM_006541217.3. [Q3U1D0-3]
DR RefSeq; XP_006541281.1; XM_006541218.3. [Q3U1D0-3]
DR RefSeq; XP_011249207.1; XM_011250905.2. [Q3U1D0-2]
DR RefSeq; XP_017167818.1; XM_017312329.1. [Q3U1D0-2]
DR AlphaFoldDB; Q3U1D0; -.
DR STRING; 10090.ENSMUSP00000112404; -.
DR iPTMnet; Q3U1D0; -.
DR PhosphoSitePlus; Q3U1D0; -.
DR EPD; Q3U1D0; -.
DR PaxDb; Q3U1D0; -.
DR PRIDE; Q3U1D0; -.
DR ProteomicsDB; 265073; -. [Q3U1D0-1]
DR ProteomicsDB; 265074; -. [Q3U1D0-2]
DR ProteomicsDB; 265075; -. [Q3U1D0-3]
DR Antibodypedia; 51579; 76 antibodies from 15 providers.
DR Ensembl; ENSMUST00000077967; ENSMUSP00000077117; ENSMUSG00000053091. [Q3U1D0-3]
DR Ensembl; ENSMUST00000121777; ENSMUSP00000112404; ENSMUSG00000053091. [Q3U1D0-1]
DR GeneID; 72635; -.
DR KEGG; mmu:72635; -.
DR UCSC; uc009hhq.2; mouse. [Q3U1D0-1]
DR UCSC; uc009hhs.2; mouse. [Q3U1D0-3]
DR CTD; 55180; -.
DR MGI; MGI:1919885; Lins1.
DR VEuPathDB; HostDB:ENSMUSG00000053091; -.
DR eggNOG; ENOG502QT6F; Eukaryota.
DR GeneTree; ENSGT00390000001790; -.
DR HOGENOM; CLU_026992_0_0_1; -.
DR InParanoid; Q3U1D0; -.
DR OMA; YRIVKCF; -.
DR OrthoDB; 222835at2759; -.
DR PhylomeDB; Q3U1D0; -.
DR TreeFam; TF332955; -.
DR BioGRID-ORCS; 72635; 2 hits in 38 CRISPR screens.
DR ChiTaRS; Lins1; mouse.
DR PRO; PR:Q3U1D0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3U1D0; protein.
DR Bgee; ENSMUSG00000053091; Expressed in granulocyte and 132 other tissues.
DR ExpressionAtlas; Q3U1D0; baseline and differential.
DR Genevisible; Q3U1D0; MM.
DR GO; GO:0050890; P:cognition; ISO:MGI.
DR InterPro; IPR029415; Lines_C.
DR InterPro; IPR032794; LINES_N.
DR InterPro; IPR024875; Protein_Lines.
DR PANTHER; PTHR16057; PTHR16057; 1.
DR Pfam; PF14695; LINES_C; 1.
DR Pfam; PF14694; LINES_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..764
FT /note="Protein Lines homolog 1"
FT /id="PRO_0000397874"
FT REGION 615..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 650
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..266
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12119551,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039707"
FT VAR_SEQ 176..180
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039708"
FT CONFLICT 450
FT /note="P -> PCA (in Ref. 2; BAE33568)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 764 AA; 85642 MW; DD059DD207EEEDF3 CRC64;
MRYILDIKME IVQEILDQLY RKVLLGTTLE DDVHGYIFYL NPDLSEQDGC PAFPVAQSNA
SGVLDGMAGQ HGPSSHEVAT LPGAQECPKR QLQMDRTREM KLLQLTVIDT MLSQVLSDET
ETHAKEGYRE LTEVLLQSVE LDSKLMRMLQ NSDKLLSHMA AKCLASLLYF QLREKVRSQH
KMLSNSWVTF CQKHLSESSE SGEAVRCLWI LTAVIKEILK DTHSQRAESL KQLLTPFDIT
FEVFYNSLFS QHFGDFQSPS NLASSLMCFL ELLELLVASR IHLKLHFRSQ RMLFLKPHAL
DILAWPIPAF IKRKLVILVK KCLLCKVGED LCREPAPSLM SPDHLLDSDM LTLADTLLHA
VHVGLWKALA VSGKPSCFGG DEVQPGCRLR TGPDHVTLRA ASLITVKSLE IKSQNCTSAA
EMKVALQTFM SELLAFLKPH LQPSLQPHNP CEWLSRVFIE QDDDMLEAAK ASLSIYLQLT
REWDASASLT QEKEAWIRST HGHGCNPHCV FLFFLKNVAF DSTVLLDFLI SSETCFLEYF
VKYLKLLQKD WAHFLSICKF FAAVESQCGM LVHDPVPSPA RGRSTSLTVP HAPASPVGEN
TCPWLPWASD ASSESQSQVM MPKETLPVPA NGPPSRTPQS LVDYDSSEAS EEETTSEHLA
NSKQTSLCQE RSEEIQGLPR TWEEQKEHSL EPLLSAESSS PFSAKGRVAA DGTVWQVGLF
LRTVKCLEEL QGAIYRLQEK NLFPYNPAAL LKLLKGVEAK CVNV
