ID   LINR_SPHJU              Reviewed;         303 AA.
AC   Q9ZN79; D4Z914;
DT   03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-JUL-2018, sequence version 3.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=HTH-type transcriptional regulator LinR;
GN   Name=linR; OrderedLocusNames=SJA_P1-01440 {ECO:0000312|EMBL:BAI99096.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 /
OS   NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S;
RX   PubMed=11916699; DOI=10.1128/aem.68.4.1803-1807.2002;
RA   Miyauchi K., Lee H.-S., Fukuda M., Takagi M., Nagata Y.;
RT   "Cloning and characterization of linR, involved in regulation of the
RT   downstream pathway for gamma-hexachlorocyclohexane degradation in
RT   Sphingomonas paucimobilis UT26.";
RL   Appl. Environ. Microbiol. 68:1803-1807(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S;
RX   PubMed=20817768; DOI=10.1128/jb.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A., Fukui S.,
RA   Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Positively regulates the transcription of the linD and linE
CC       genes that are involved in gamma-hexachlorocyclohexane (gamma-HCH or
CC       lindane) degradation. This degradation pathway allows S.japonicum UT26
CC       to grow on gamma-HCH as the sole source of carbon and energy.
CC       {ECO:0000269|PubMed:11916699}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AB021863; BAA36280.1; -; Genomic_DNA.
DR   EMBL; AP010805; BAI99096.1; -; Genomic_DNA.
DR   RefSeq; WP_013041683.1; NC_014007.1.
DR   AlphaFoldDB; Q9ZN79; -.
DR   SMR; Q9ZN79; -.
DR   EnsemblBacteria; BAI99096; BAI99096; SJA_P1-01440.
DR   KEGG; sjp:SJA_P1-01440; -.
DR   HOGENOM; CLU_039613_39_0_5; -.
DR   OMA; MMNIMHP; -.
DR   Proteomes; UP000007753; Plasmid pCHQ1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..303
FT                   /note="HTH-type transcriptional regulator LinR"
FT                   /id="PRO_0000105662"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        191
FT                   /note="M -> T (in Ref. 1; BAA36280)"
FT   CONFLICT        251
FT                   /note="I -> T (in Ref. 1; BAA36280)"
SQ   SEQUENCE   303 AA;  33638 MW;  E1C7DE05E19ECEE5 CRC64;
     MNIDDLDFRH LVLLDALLKR HSVSAAAREL DLPQPTASHG LARLRKALGD PLLVRARDGM
     EPTPRAEAIA GVVQQLLELR RDLAEGGQTF SPDRLKREFI IAGSDIAHLV VLTALHSAAR
     FEAPHTSYRA LTLSGDEMVS ALETGHVDIA VGAYPSLVAG IKTQRLYQEE YLCFGKEGHP
     FIKSGETDDF MAADHIVVST KGMAHAHRAV ERALLDKIHP DRIRIVASSF LVALAACFES
     DLILTAPARV IGRLAEVYGL RAVRPPILME AFEVRQYWHA RNQDDPPHRW LRQLLHKVLS
     ARM