ID   LIP10_CANAL             Reviewed;         465 AA.
AC   Q9P4E5; A0A1D8PEM6; Q5APE3;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Lipase 10;
DE            EC=3.1.1.3;
DE   Flags: Precursor;
GN   Name=LIP10; OrderedLocusNames=CAALFM_C109590CA;
GN   ORFNames=CaO19.12285, CaO19.4822;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11131027; DOI=10.1007/s002030000218;
RA   Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.;
RT   "Secreted lipases of Candida albicans: cloning, characterisation and
RT   expression analysis of a new gene family with at least ten members.";
RL   Arch. Microbiol. 174:362-374(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC         H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11131027}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
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DR   EMBL; AF191323; AAF79930.1; -; Genomic_DNA.
DR   EMBL; CP017623; AOW26591.1; -; Genomic_DNA.
DR   RefSeq; XP_723508.1; XM_718415.1.
DR   AlphaFoldDB; Q9P4E5; -.
DR   SMR; Q9P4E5; -.
DR   STRING; 237561.Q9P4E5; -.
DR   ESTHER; canal-LIP10; Fungal-Bact_LIP.
DR   PRIDE; Q9P4E5; -.
DR   GeneID; 3634889; -.
DR   KEGG; cal:CAALFM_C109590CA; -.
DR   CGD; CAL0000198152; LIP10.
DR   VEuPathDB; FungiDB:C1_09590C_A; -.
DR   eggNOG; ENOG502S2P7; Eukaryota.
DR   HOGENOM; CLU_029538_5_0_1; -.
DR   InParanoid; Q9P4E5; -.
DR   OMA; KIFSYQV; -.
DR   OrthoDB; 838782at2759; -.
DR   PRO; PR:Q9P4E5; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016298; F:lipase activity; IDA:CGD.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005152; Lipase_secreted.
DR   PANTHER; PTHR34853; PTHR34853; 1.
DR   Pfam; PF03583; LIP; 1.
DR   PIRSF; PIRSF029171; Esterase_LipA; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..465
FT                   /note="Lipase 10"
FT                   /id="PRO_0000017829"
FT   ACT_SITE        196
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        344
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        319
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  50469 MW;  969A90F0ACC71A6B CRC64;
     MKTLLIFLAF LSSIFASLIG LTPPSKDSFY SPPVGFATAK PGDILKIRNT PSAPSSLYLP
     IVVKNAWQLL IRSEDSFGNP NAFVATLIQP LNANPSKLVS YQSWEDASHI DCSPSYGMQF
     KSPATTVTTQ IDMTLIVPLL QNGYYVIIPD YEGPKSTFTV GRQSGKATLN SIRAALQTGA
     FSGIKKTAKV ALWGYSGGSL ATGWAISLQS KYAPELKENL IGAAVGGFAT NITAVAEAVD
     GTVFSGFIPL ALNGLANEYP DFKKRLYGEV KLSARSTMEK GSQNCLAASL VGYPMSQYFT
     GQNRAFEKGW GLLQDEVFNK TIEDNLLLKL DKTYLPQVPV LIYHGTIDEI IPIKDANAQY
     QIWCDRGIQS LEFAEDLSAG HLAETFTGAP AALSWIDARF SGKPAVNGCQ RTIRSSNVLY
     PGISITIRIY FEGISKTIFG VNLGSGVNAD KSISNKFFAY IRKYI