ID   LIP1_ASHGO              Reviewed;         141 AA.
AC   Q751M6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ceramide synthase subunit LIP1;
GN   Name=LIP1; OrderedLocusNames=AGL329C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the ceramide synthase complex required for
CC       synthesis of ceramides. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ceramide synthase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIP1 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54162.1; -; Genomic_DNA.
DR   RefSeq; NP_986338.1; NM_211400.1.
DR   AlphaFoldDB; Q751M6; -.
DR   STRING; 33169.AAS54162; -.
DR   EnsemblFungi; AAS54162; AAS54162; AGOS_AGL329C.
DR   GeneID; 4622631; -.
DR   KEGG; ago:AGOS_AGL329C; -.
DR   eggNOG; ENOG502S1YW; Eukaryota.
DR   HOGENOM; CLU_1759093_0_0_1; -.
DR   InParanoid; Q751M6; -.
DR   OMA; CDKRGEL; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0061576; C:acyl-CoA ceramide synthase complex; IEA:EnsemblFungi.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050291; F:sphingosine N-acyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IEA:EnsemblFungi.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Lipid biosynthesis; Lipid metabolism;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Ceramide synthase subunit LIP1"
FT                   /id="PRO_0000308778"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        4..26
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..141
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   141 AA;  15669 MW;  FDF47123A1FB2B3F CRC64;
     MAIGRYGTLV FYILAGLAFV WSLEYFKHYT KNNYERFHCT AVVEPVQGTA TVEKLSAVGG
     PPCDKRAELK LITQKLTQHF DPNKQPALFC IVENTSVESV HYPVSRTNKG PAGYIAYAGY
     EADRAAVHKY CEAHGAAVLH M