ID   LIP1_MORS1              Reviewed;         319 AA.
AC   P19833;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Lipase 1;
DE            EC=3.1.1.3;
DE   AltName: Full=Triacylglycerol lipase;
GN   Name=lip1; Synonyms=L1;
OS   Moraxella sp. (strain TA144).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Moraxella; unclassified Moraxella.
OX   NCBI_TaxID=77152;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2243791; DOI=10.1093/nar/18.21.6431;
RA   Feller G., Thiry M., Gerday C.;
RT   "Sequence of a lipase gene from the antarctic psychrotroph Moraxella
RT   TA144.";
RL   Nucleic Acids Res. 18:6431-6431(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC         H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Temperature dependence:
CC         Active at temperatures close to 0 degree Celsius.;
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DR   EMBL; X53053; CAA37220.1; -; Genomic_DNA.
DR   PIR; S12104; S12104.
DR   AlphaFoldDB; P19833; -.
DR   SMR; P19833; -.
DR   ESTHER; morsp-lip1; Polyesterase-lipase-cutinase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Calcium; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding.
FT   CHAIN           1..319
FT                   /note="Lipase 1"
FT                   /id="PRO_0000090352"
FT   ACT_SITE        189
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   BINDING         314
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         317
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   319 AA;  34624 MW;  451E5D26B1404383 CRC64;
     MFIMIKKSEL AKAIIVTGAL VFSIPTLAEV TLSETTVSSI KSEATVSSTK KALPATPSDC
     IADSKITAVA LSDTRDNGPF SIRTKRISRQ SAKGFGGGTI HYPTNASGCG LLGAIAVVPG
     YVSYENSIKW WGPRLASWGF VVITINTNSI YDDPDSRAAQ LNAALDNMIA DDTVGSMIDP
     KRLGAIGWSM GGGGALKLAT ERSTVRAIMP LAPYHDKSYG EVKTPTLVIA CEDDRIAETK
     KYANAFYKNA IGPKMKVEVN NGSHFCPSYR FNEILLSKPG IAWMQRYINN DTRFDKFLCA
     NENYSKSPRI SAYDYKDCP