ID   LIP1_YEAS7              Reviewed;         150 AA.
AC   A6ZN14;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Ceramide synthase subunit LIP1;
GN   Name=LIP1; ORFNames=SCY_4480;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the ceramide synthase complex required for
CC       synthesis of ceramides. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ceramide synthase complex composed of at
CC       least LAC1, LAG1 and LIP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIP1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000021; EDN64238.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZN14; -.
DR   EnsemblFungi; EDN64238; EDN64238; SCY_4480.
DR   HOGENOM; CLU_1759093_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..150
FT                   /note="Ceramide synthase subunit LIP1"
FT                   /id="PRO_0000308781"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..40
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..150
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   150 AA;  17207 MW;  75DBA35225C3065C CRC64;
     MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW FHCTPIKEPQ
     SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS FCIIENDNVP PVHYPIHEDK
     GEPGYVAYVG YDTDSELVQE LCADSTIYHM