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LIP3_DROME
ID   LIP3_DROME              Reviewed;         394 AA.
AC   O46108; Q4V3U9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Lipase 3;
DE            Short=DmLip3;
DE            EC=3.1.1.-;
DE   Flags: Precursor;
GN   Name=Lip3; ORFNames=CG8823;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Canton-S;
RX   PubMed=9566193; DOI=10.1006/jmbi.1997.1536;
RA   Pistillo D., Manzi A., Tino A., Pilo Boyl P., Graziani F., Malva C.;
RT   "The Drosophila melanogaster lipase homologs: a gene family with tissue and
RT   developmental specific expression.";
RL   J. Mol. Biol. 276:877-885(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- TISSUE SPECIFICITY: Fat body. {ECO:0000269|PubMed:9566193}.
CC   -!- DEVELOPMENTAL STAGE: Only at larval stages.
CC       {ECO:0000269|PubMed:9566193}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
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DR   EMBL; Y14367; CAA74737.1; -; mRNA.
DR   EMBL; AE014297; AAF54935.1; -; Genomic_DNA.
DR   EMBL; BT023257; AAY55673.1; -; mRNA.
DR   RefSeq; NP_477331.1; NM_057983.4.
DR   AlphaFoldDB; O46108; -.
DR   SMR; O46108; -.
DR   BioGRID; 66726; 13.
DR   IntAct; O46108; 12.
DR   STRING; 7227.FBpp0082239; -.
DR   ESTHER; drome-lip3; Acidic_Lipase.
DR   GlyGen; O46108; 1 site.
DR   PaxDb; O46108; -.
DR   DNASU; 41643; -.
DR   EnsemblMetazoa; FBtr0082771; FBpp0082239; FBgn0023495.
DR   GeneID; 41643; -.
DR   KEGG; dme:Dmel_CG8823; -.
DR   UCSC; CG8823-RA; d. melanogaster.
DR   CTD; 41643; -.
DR   FlyBase; FBgn0023495; Lip3.
DR   VEuPathDB; VectorBase:FBgn0023495; -.
DR   eggNOG; KOG2624; Eukaryota.
DR   GeneTree; ENSGT00940000165260; -.
DR   HOGENOM; CLU_010974_0_3_1; -.
DR   InParanoid; O46108; -.
DR   OMA; HKYWPTY; -.
DR   OrthoDB; 651396at2759; -.
DR   PhylomeDB; O46108; -.
DR   Reactome; R-DME-192456; Digestion of dietary lipid.
DR   Reactome; R-DME-6809371; Formation of the cornified envelope.
DR   SignaLink; O46108; -.
DR   BioGRID-ORCS; 41643; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 41643; -.
DR   PRO; PR:O46108; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0023495; Expressed in midgut and 5 other tissues.
DR   ExpressionAtlas; O46108; baseline and differential.
DR   Genevisible; O46108; DM.
DR   GO; GO:0004806; F:triglyceride lipase activity; IDA:FlyBase.
DR   GO; GO:0016042; P:lipid catabolic process; IDA:FlyBase.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   InterPro; IPR025483; Lipase_euk.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00120; LIPASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..394
FT                   /note="Lipase 3"
FT                   /id="PRO_0000017811"
FT   ACT_SITE        164
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT   ACT_SITE        369
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   394 AA;  44901 MW;  A718D1D743673802 CRC64;
     MTRGALKVTI LLVGLGLVLA GSRPISDCGE RIEDDGYPME RHEVVTSDNY ILTMHRIPYS
     PKTGESSNRP VAFLMHGMLS SSSDWVLMGP ERSLAYMLAD AGYDVWMGNA RGNTYSKAHK
     YWPTYWQIFW NFSWNEIGMY DVPAMIDYVL AKTGQQQVQY VGHSQGTTVY LVMVSERPEY
     NDKIKSAHLL GPAAYMGNMK SPLTRAFAPI LGQPNAIVEV CGSMEFMPSN KFKQDLGIEM
     CQATSPYADM CANEIFLIGG YDTEQLDYEL LEHIKATSPA GASVNQNLHF CQEYNSGKFR
     KFDYTALRNP YEYGSYFPPD YKLKNAKAPV LLYYGANDWM CDVSDVRKLR DELPNMALDY
     LVPFEKWAHL DFIWGTEARK YVYDEVLKQM QSYE
 
 
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