LIP5_CANAL
ID LIP5_CANAL Reviewed; 463 AA.
AC Q9P8W0; A0A1D8PR71; Q3MP71; Q5A5A1;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Lipase 5;
DE EC=3.1.1.3;
DE Flags: Precursor;
GN Name=LIP5; OrderedLocusNames=CAALFM_C702830CA;
GN ORFNames=CaJ7.0322, CaO19.12646, CaO19.5179;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=11131027; DOI=10.1007/s002030000218;
RA Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.;
RT "Secreted lipases of Candida albicans: cloning, characterisation and
RT expression analysis of a new gene family with at least ten members.";
RL Arch. Microbiol. 174:362-374(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA Mikami Y.;
RT "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT syntenic analysis against the Saccharomyces cerevisiae genome.";
RL Genetics 170:1525-1537(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11131027}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000305}.
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DR EMBL; AF191318; AAF69522.1; -; Genomic_DNA.
DR EMBL; AP006852; BAE44789.1; -; Genomic_DNA.
DR EMBL; CP017629; AOW30630.1; -; Genomic_DNA.
DR RefSeq; XP_717001.1; XM_711908.1.
DR AlphaFoldDB; Q9P8W0; -.
DR SMR; Q9P8W0; -.
DR ESTHER; canal-LIP5; Fungal-Bact_LIP.
DR GeneID; 3641356; -.
DR KEGG; cal:CAALFM_C702830CA; -.
DR CGD; CAL0000176626; LIP5.
DR VEuPathDB; FungiDB:C7_02830C_A; -.
DR eggNOG; ENOG502SI7U; Eukaryota.
DR HOGENOM; CLU_029538_5_0_1; -.
DR InParanoid; Q9P8W0; -.
DR OrthoDB; 806580at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IDA:CGD.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005152; Lipase_secreted.
DR PANTHER; PTHR34853; PTHR34853; 1.
DR Pfam; PF03583; LIP; 1.
DR PIRSF; PIRSF029171; Esterase_LipA; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..14
FT /evidence="ECO:0000255"
FT CHAIN 15..463
FT /note="Lipase 5"
FT /id="PRO_0000017824"
FT ACT_SITE 194
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 339
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 275
FT /note="D -> E (in Ref. 1; AAF69522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 463 AA; 49963 MW; B1772055F5E7CD65 CRC64;
MLYLILFLIA PIYAGLIFPT KPSSDPFYNP PKGFENAAVG DILQSRATPK SITGGFTPLK
IQNSWQLLVR SEDSFGNPNV IVTTVIEPVN ADPSKIASYQ VFEDAAKADC APSYALQFGS
DLTTFVTQAE MYLMAPLLDQ GYYVVSPDYE GPKSTFTIGK QSGQAVLNSI RAALKSGKIT
NIKDDAKVVM WGYSGGSLAS GWAAALQPSY APELGGNLLG AALGGFVTNI TATAQATDGT
VFAGIVANAL GGVANEYPEF KSILQSDTDK KSVFDEFDGH CLIDGVLNYI GTSFLTGDHK
IFKTGWDILK NPKIGKVVED NGLVYQKQLV PKIPVFIYHG SIDQIVPIVD TKKTYQNWCD
AGISSLEFAE DASNGHLTEA IMGAPAALTW IIDRFDGKQT VSGCQHIQRF SNLEYPNIPS
SIANYFKAAM DVVLHLGLGP DVQKDQVSPE GIKKLGSIEM RWL
