ID   LIP6_CANAL              Reviewed;         463 AA.
AC   Q9P4E8; A0A1D8PEM2; Q5APE2;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Lipase 6;
DE            EC=3.1.1.3;
DE   Flags: Precursor;
GN   Name=LIP6; OrderedLocusNames=CAALFM_C109600CA;
GN   ORFNames=CaO19.12286, CaO19.4823;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11131027; DOI=10.1007/s002030000218;
RA   Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.;
RT   "Secreted lipases of Candida albicans: cloning, characterisation and
RT   expression analysis of a new gene family with at least ten members.";
RL   Arch. Microbiol. 174:362-374(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC         H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11131027}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF191319; AAF79927.1; -; Genomic_DNA.
DR   EMBL; CP017623; AOW26592.1; -; Genomic_DNA.
DR   RefSeq; XP_723509.1; XM_718416.1.
DR   AlphaFoldDB; Q9P4E8; -.
DR   SMR; Q9P4E8; -.
DR   BioGRID; 1217984; 1.
DR   ESTHER; canal-LIP6; Fungal-Bact_LIP.
DR   GeneID; 3634890; -.
DR   KEGG; cal:CAALFM_C109600CA; -.
DR   CGD; CAL0000176920; LIP6.
DR   VEuPathDB; FungiDB:C1_09600C_A; -.
DR   eggNOG; ENOG502S2P7; Eukaryota.
DR   HOGENOM; CLU_029538_5_0_1; -.
DR   InParanoid; Q9P4E8; -.
DR   OMA; RQYCATG; -.
DR   OrthoDB; 838782at2759; -.
DR   PRO; PR:Q9P4E8; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016298; F:lipase activity; IDA:CGD.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005152; Lipase_secreted.
DR   PANTHER; PTHR34853; PTHR34853; 1.
DR   Pfam; PF03583; LIP; 1.
DR   PIRSF; PIRSF029171; Esterase_LipA; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..463
FT                   /note="Lipase 6"
FT                   /id="PRO_0000017825"
FT   ACT_SITE        196
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        344
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  50480 MW;  21F5E66B04F73DAF CRC64;
     MRDLILFLSL LHTIFASLFS LKPPSQDDFY KAPAGFKAAK PGDILKTRKS PNKPSSLYAP
     VDVQNSWQLL VRSEDSFGNP NAFVTTIIQP KNADPSKVVS YQNWEDASNI NCSPSYGSQL
     GAPLSTILTQ LDMTFIVPPL KSGYYVVLPD YEGPKSTFGV GRQSGKATLD SIKAVLKTKD
     FSGINDDAKV VLWGYSGGSF ASGWAAVLQP EYAPELKDNL IGAALGGFAA NLTGIAESVD
     GEVFSGFIPL ALNGIANEYP DFKKRLYEEV KPGAKADLQK GAENCLAASL ISYPMYQYFT
     GPRRVFEKGW SLLEDKTIGK TLEDNLLIAL SKEHMPQIPI FVYHGTIDKI IPIKDSIKIY
     KNWCDWGIGS FEFSEDKSNG HTTETVVGAP AALTWIDARF AGKPAVEGCS FTTRASNFLY
     PNISESAASY FKGIYQTILR SKLGSGVTSD DVSVNGLRSL YHT