LIP7_CANAL
ID LIP7_CANAL Reviewed; 426 AA.
AC Q9P4E7; A0A1D8PTZ0; Q5A3Y9;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Lipase 7;
DE EC=3.1.1.3;
DE Flags: Precursor;
GN Name=LIP7; OrderedLocusNames=CAALFM_CR09220CA; ORFNames=CaO19.7320;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=11131027; DOI=10.1007/s002030000218;
RA Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.;
RT "Secreted lipases of Candida albicans: cloning, characterisation and
RT expression analysis of a new gene family with at least ten members.";
RL Arch. Microbiol. 174:362-374(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11131027}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000305}.
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DR EMBL; AF191320; AAF79928.1; -; Genomic_DNA.
DR EMBL; CP017630; AOW31587.1; -; Genomic_DNA.
DR RefSeq; XP_716454.1; XM_711361.1.
DR AlphaFoldDB; Q9P4E7; -.
DR SMR; Q9P4E7; -.
DR ESTHER; canal-LIP7; Fungal-Bact_LIP.
DR GeneID; 3641917; -.
DR KEGG; cal:CAALFM_CR09220CA; -.
DR CGD; CAL0000199825; LIP7.
DR VEuPathDB; FungiDB:CR_09220C_A; -.
DR eggNOG; ENOG502S2P7; Eukaryota.
DR HOGENOM; CLU_029538_5_0_1; -.
DR InParanoid; Q9P4E7; -.
DR OMA; DMSYNHM; -.
DR OrthoDB; 838782at2759; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR005152; Lipase_secreted.
DR PANTHER; PTHR34853; PTHR34853; 1.
DR Pfam; PF03583; LIP; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..426
FT /note="Lipase 7"
FT /id="PRO_0000017826"
FT ACT_SITE 190
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 321
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 423
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 426 AA; 47854 MW; 2DBBABC4CBCC6A85 CRC64;
MFVFLALITL TTCLQIPLNP TIDDFYNPPK DLETSQLGDV LKWRKMPFPV TSMFVNLPIS
NAWQISVRSQ DTLNNSLAIV ATILEPPNGD KNKLISHQAF ENSPLLSCSP SYSMQVPSFE
TFQIQADLIF ISGLLSQGWY VVVPDYEGPN SVFPVGRQSA YSVLDSIRGT IKFFNSTGNS
TVKTALLGYS YGAVASLWAS IVQPNYAPEL ELVGAAVGCT IPNITAFIEK VDEGPYSGLI
VNIFNGLANE YRHFRDRLIH FGALQPLGCL FPICRKFFFQ KMIGGVYDAQ VLTDETIKET
IEINNLLSTR AVPQIPVFLF HSKFNEMSPF LEILKLEKLW CSQLGVNLEI AEDMSYNHMV
EAFSGMPAAI TWIEKRWNNS TLGGCKHVHR LSNFEYPGIA PFLSQYFRSS LQMVLNNNRY
FNNTTR
