ID   LIP9_CANAL              Reviewed;         453 AA.
AC   Q9P4E6; A0A1D8PR77; Q5A5A8;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 3.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Lipase 9;
DE            EC=3.1.1.3;
DE   Flags: Precursor;
GN   Name=LIP9; OrderedLocusNames=CAALFM_C702880CA;
GN   ORFNames=CaO19.12639, CaO19.5172;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11131027; DOI=10.1007/s002030000218;
RA   Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W.;
RT   "Secreted lipases of Candida albicans: cloning, characterisation and
RT   expression analysis of a new gene family with at least ten members.";
RL   Arch. Microbiol. 174:362-374(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC         H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11131027}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
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DR   EMBL; AF191322; AAF79929.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30635.1; -; Genomic_DNA.
DR   RefSeq; XP_716995.2; XM_711902.2.
DR   AlphaFoldDB; Q9P4E6; -.
DR   SMR; Q9P4E6; -.
DR   STRING; 237561.Q9P4E6; -.
DR   ESTHER; canal-LIP9; Fungal-Bact_LIP.
DR   GeneID; 3641395; -.
DR   KEGG; cal:CAALFM_C702880CA; -.
DR   CGD; CAL0000191620; LIP9.
DR   VEuPathDB; FungiDB:C7_02880C_A; -.
DR   eggNOG; ENOG502SI7U; Eukaryota.
DR   HOGENOM; CLU_122001_0_0_1; -.
DR   InParanoid; Q9P4E6; -.
DR   OrthoDB; 838782at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005152; Lipase_secreted.
DR   PANTHER; PTHR34853; PTHR34853; 1.
DR   Pfam; PF03583; LIP; 1.
DR   PIRSF; PIRSF029171; Esterase_LipA; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..453
FT                   /note="Lipase 9"
FT                   /id="PRO_0000017828"
FT   ACT_SITE        194
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        339
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        266
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        269
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        417
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        245
FT                   /note="I -> T (in Ref. 1; AAF79929)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   453 AA;  49232 MW;  6F96E2D0323F7FEE CRC64;
     MLYLILFLIA PIYAGVLLPT KPSIDPFYNA PEGFKNATVG DILQFRKTPK SITGGFVPLN
     VQNSWQFLVR SEDSFGNPNV IVTTVIEPVN ADPSKIASYQ VSENAARADC APSYALQFGS
     DVSTLATQAE TYLLAPLLDK GYYVVSPDYE GPKSTFTVGK QSGQAVLNSI RASLKSGKIT
     NIAEDAKVLM WGYSGGSLAS GWAAALQPDY APELSRNLLG VALGGFITNV TATVEATDDT
     IFAGIAANVL GGIANEYPEF KSILQNDTNK SSIFNKINNH CLTDSFIKYV GARFLTGDNK
     VFKSGWNIFK NLVVSKIVKD NGLVYQKQLI PTIPVFIYHG SMDQISPILN PKKTYQNWCD
     AGISSIEFAE DLTNGHFTES IVGAPAALTW IIDRFSNKPP VDGCQHVVRT TNYEYPNVSS
     SILDYFKAAM DVVAQQGLGP NIQKDQLEIK SNL