ID   LIPA_MYCPU              Reviewed;         578 AA.
AC   Q50274; Q98Q39;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 3.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Lipoprotein A;
DE   Flags: Precursor;
GN   Name=lipA; OrderedLocusNames=MYPU_5300;
OS   Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX   NCBI_TaxID=272635;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KD735-15;
RX   PubMed=10781561; DOI=10.1128/jb.182.10.2900-2908.2000;
RA   Shen X., Gumulak J., Yu H., French C.T., Zou N., Dybvig K.;
RT   "Gene rearrangements in the vsa locus of Mycoplasma pulmonis.";
RL   J. Bacteriol. 182:2900-2908(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP;
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT   pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
RN   [3]
RP   PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KD735-15;
RX   PubMed=8817492; DOI=10.1111/j.1365-2958.1995.mmi_18040703.x;
RA   Bhugra B., Voelker L.L., Zou N., Yu H., Dybvig K.;
RT   "Mechanism of antigenic variation in Mycoplasma pulmonis: interwoven, site-
RT   specific DNA inversions.";
RL   Mol. Microbiol. 18:703-714(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- SIMILARITY: Belongs to the M.pulmonis LipAB lipoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; U23947; AAB41030.2; -; Genomic_DNA.
DR   EMBL; AL445565; CAC13703.1; -; Genomic_DNA.
DR   PIR; B90578; B90578.
DR   RefSeq; WP_010925331.1; NC_002771.1.
DR   AlphaFoldDB; Q50274; -.
DR   PRIDE; Q50274; -.
DR   EnsemblBacteria; CAC13703; CAC13703; CAC13703.
DR   KEGG; mpu:MYPU_5300; -.
DR   HOGENOM; CLU_020409_1_0_14; -.
DR   OrthoDB; 2151731at2; -.
DR   BioCyc; MPUL272635:G1GT6-538-MON; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007326; Lipoprotein-assoc_dom.
DR   Pfam; PF04200; Lipoprotein_17; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           28..578
FT                   /note="Lipoprotein A"
FT                   /id="PRO_0000018235"
FT   REGION          35..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           28
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           28
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   VARIANT         7
FT                   /note="K -> R (in strain: KD735-15)"
FT   VARIANT         41
FT                   /note="N -> S (in strain: KD735-15)"
FT   VARIANT         110
FT                   /note="N -> D (in strain: KD735-15)"
FT   VARIANT         127
FT                   /note="S -> A (in strain: KD735-15)"
FT   VARIANT         547
FT                   /note="Y -> N (in strain: KD735-15)"
SQ   SEQUENCE   578 AA;  66219 MW;  B533ED3467005D89 CRC64;
     MNKKYFKKYS WVLILSTSIL APMTLASCNH NVAKKEDKTQ NDSSNLSNKT NKSDPNDHLK
     DKDKNVSQDN KDSTNKAVSN ENSQTQSQKT NESSQNTKDD SSKTSNLITN QNSSSNTKSK
     IQENKQSQKD QNTSAVNVSA LEKQTKNDEN ISLVNSKDTN VILKNDEKVA LAKDDSKEKS
     KNSSNLNLKT PVENRQNKNE VKDDKKALQW WQKLNESASI LESFSYDQTS LSLTFKEGMP
     LGLEVVLKLE NLDSHEEKEI SFKTTNGKVQ NVLLTSSNLT SGKWKIKSFS FDKTYSHSPT
     IETTFDFKTN EKLKQERIEK IQKAIDKYQI KIKQNYKDKP LISKYALSNF DLNLNFKDLE
     IVNNSLKFDG SNLNQDLKSE KQMKITFEKV SENQANKTRK AHFKITTLDN LVFEKTLEWS
     YKTNKEYLDE FKNGSALWDD LQASLTSVFE KSLWHPYQLP KAKSKINTIN LINDVSASFQ
     GYDYLDDFNG SAKLKFKLQR GQEQRDITFT INGFLKVSLI DPLYKGNLRN SEFDVKASSN
     GYWLGQYYTA AEVFKHYSNG KSYWYATAND GNPWLEFS