LIPB_CAEEL
ID LIPB_CAEEL Reviewed; 1004 AA.
AC Q94071; A0A131MBC5; A0A131MBE2; A0A131MBV4; A0A131MBW2; A0A131MBW4;
AC A0A131MBY3; A0A131MBZ3; A0A131MC19; A0A131MC32; A0A131MCT0; A0A131MD42;
AC A0A131MD54; A0A131MD98; A0A131MDA8; A0A131MDI4; A0A131MDJ4; A7LPI2; Q94075;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 5.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Liprin-beta homolog {ECO:0000312|WormBase:T21H8.1h};
DE AltName: Full=LAR-interacting protein beta;
GN Name=hlb-1 {ECO:0000312|WormBase:T21H8.1h};
GN ORFNames=T21H8.1 {ECO:0000312|WormBase:T21H8.1h};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=9624153; DOI=10.1074/jbc.273.25.15611;
RA Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.;
RT "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-
RT interacting proteins.";
RL J. Biol. Chem. 273:15611-15620(1998).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19290026; DOI=10.1007/s12264-009-0119-9;
RA Wang D.Y., Wang Y.;
RT "HLB-1 functions as a new regulator for the organization and function of
RT neuromuscular junctions in nematode Caenorhabditis elegans.";
RL Neurosci. Bull. 25:75-86(2009).
CC -!- FUNCTION: Involved in the regulation of synaptic function at
CC neuromuscular junctions (PubMed:19290026). Together with the liprin-
CC alpha protein syd-2, may play a role in regulating the structure of the
CC neuronal region, called the active zone, from which synaptic vesicles
CC send neurotransmitter signals across the synapse (PubMed:19290026).
CC Does not seem to be required for neuronal development
CC (PubMed:19290026). May regulate the disassembly of focal adhesions (By
CC similarity). Does not bind receptor-like tyrosine phosphatases type 2A
CC (By similarity). {ECO:0000250|UniProtKB:Q86W92,
CC ECO:0000269|PubMed:19290026}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=19;
CC Name=h {ECO:0000312|WormBase:T21H8.1h};
CC IsoId=Q94071-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:T21H8.1a};
CC IsoId=Q94071-2; Sequence=VSP_060304, VSP_060306, VSP_060310;
CC Name=b {ECO:0000312|WormBase:T21H8.1b};
CC IsoId=Q94071-3; Sequence=VSP_060304, VSP_060306;
CC Name=c {ECO:0000312|WormBase:T21H8.1c};
CC IsoId=Q94071-4; Sequence=VSP_060304, VSP_060306, VSP_060309,
CC VSP_060310;
CC Name=d {ECO:0000312|WormBase:T21H8.1d};
CC IsoId=Q94071-5; Sequence=VSP_060304, VSP_060306, VSP_060309;
CC Name=e {ECO:0000312|WormBase:T21H8.1e};
CC IsoId=Q94071-6; Sequence=VSP_060300, VSP_060310;
CC Name=f {ECO:0000312|WormBase:T21H8.1f};
CC IsoId=Q94071-7; Sequence=VSP_060300;
CC Name=g {ECO:0000312|WormBase:T21H8.1g};
CC IsoId=Q94071-8; Sequence=VSP_060310;
CC Name=i {ECO:0000312|WormBase:T21H8.1i};
CC IsoId=Q94071-9; Sequence=VSP_060305, VSP_060310;
CC Name=j {ECO:0000312|WormBase:T21H8.1j};
CC IsoId=Q94071-10; Sequence=VSP_060305;
CC Name=k {ECO:0000312|WormBase:T21H8.1k};
CC IsoId=Q94071-11; Sequence=VSP_060303, VSP_060310;
CC Name=l {ECO:0000312|WormBase:T21H8.1l};
CC IsoId=Q94071-12; Sequence=VSP_060303;
CC Name=m {ECO:0000312|WormBase:T21H8.1m};
CC IsoId=Q94071-13; Sequence=VSP_060302, VSP_060310;
CC Name=n {ECO:0000312|WormBase:T21H8.1n};
CC IsoId=Q94071-14; Sequence=VSP_060302;
CC Name=o {ECO:0000312|WormBase:T21H8.1o};
CC IsoId=Q94071-15; Sequence=VSP_060307, VSP_060308;
CC Name=p {ECO:0000312|WormBase:T21H8.1p};
CC IsoId=Q94071-16; Sequence=VSP_060305, VSP_060307, VSP_060308;
CC Name=q {ECO:0000312|WormBase:T21H8.1q};
CC IsoId=Q94071-17; Sequence=VSP_060303, VSP_060307, VSP_060308;
CC Name=r {ECO:0000312|WormBase:T21H8.1r};
CC IsoId=Q94071-18; Sequence=VSP_060301, VSP_060310;
CC Name=s {ECO:0000312|WormBase:T21H8.1s};
CC IsoId=Q94071-19; Sequence=VSP_060301;
CC -!- TISSUE SPECIFICITY: Expressed in pharyngeal muscle, particularly
CC posterior bulb, adjacent to the dorsal and ventral cord (but not in
CC ventral cord neurons), and in body wall muscles.
CC {ECO:0000269|PubMed:9624153}.
CC -!- DISRUPTION PHENOTYPE: Defective locomotion, reduced pumping rate and
CC reduced brood size (PubMed:19290026). Defects in presynaptic and
CC postsynaptic structures and functions in muscle cells
CC (PubMed:19290026). Resistant to the acetylcholinesterase inhibitor
CC aldicarb and to levamisole, an agonist for postsynaptic acetylcholine
CC receptors in muscles (PubMed:19290026). Double knockout with the syd-2
CC mutant ju37 increases resistance to aldicarb and levamisole
CC (PubMed:19290026). {ECO:0000269|PubMed:19290026}.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-beta subfamily.
CC {ECO:0000305}.
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DR EMBL; BX284606; CAB01770.1; -; Genomic_DNA.
DR EMBL; BX284606; CAB01771.3; -; Genomic_DNA.
DR EMBL; BX284606; CAO79773.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14633.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14634.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14635.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14636.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14637.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14638.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14639.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14640.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14641.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14642.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14643.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14644.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14645.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14646.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14647.1; -; Genomic_DNA.
DR EMBL; BX284606; CZR14648.1; -; Genomic_DNA.
DR PIR; A89696; A89696.
DR PIR; T25087; T25087.
DR PIR; T25088; T25088.
DR RefSeq; NP_001123185.1; NM_001129713.2. [Q94071-3]
DR RefSeq; NP_001309703.1; NM_001322655.1. [Q94071-4]
DR RefSeq; NP_001309704.1; NM_001322656.1. [Q94071-5]
DR RefSeq; NP_001309705.1; NM_001322659.1. [Q94071-6]
DR RefSeq; NP_001309706.1; NM_001322660.1. [Q94071-7]
DR RefSeq; NP_001309707.1; NM_001322647.1. [Q94071-8]
DR RefSeq; NP_001309708.1; NM_001322648.1. [Q94071-1]
DR RefSeq; NP_001309709.1; NM_001322649.1. [Q94071-9]
DR RefSeq; NP_001309710.1; NM_001322650.1. [Q94071-10]
DR RefSeq; NP_001309711.1; NM_001322651.1.
DR RefSeq; NP_001309712.1; NM_001322652.1.
DR RefSeq; NP_001309713.1; NM_001322653.1. [Q94071-13]
DR RefSeq; NP_001309714.1; NM_001322654.1. [Q94071-14]
DR RefSeq; NP_001309715.1; NM_001322661.1.
DR RefSeq; NP_001309716.1; NM_001322662.1. [Q94071-17]
DR RefSeq; NP_001309717.1; NM_001322657.1. [Q94071-18]
DR RefSeq; NP_001309718.1; NM_001322658.1. [Q94071-19]
DR RefSeq; NP_510311.2; NM_077910.4. [Q94071-2]
DR RefSeq; NP_510312.1; NM_077911.1.
DR AlphaFoldDB; Q94071; -.
DR SMR; Q94071; -.
DR BioGRID; 46399; 1.
DR IntAct; Q94071; 2.
DR STRING; 6239.T21H8.1b.1; -.
DR EPD; Q94071; -.
DR PaxDb; Q94071; -.
DR PeptideAtlas; Q94071; -.
DR EnsemblMetazoa; T21H8.1a.1; T21H8.1a.1; WBGene00011904. [Q94071-2]
DR EnsemblMetazoa; T21H8.1b.1; T21H8.1b.1; WBGene00011904. [Q94071-3]
DR EnsemblMetazoa; T21H8.1c.1; T21H8.1c.1; WBGene00011904. [Q94071-4]
DR EnsemblMetazoa; T21H8.1d.1; T21H8.1d.1; WBGene00011904. [Q94071-5]
DR EnsemblMetazoa; T21H8.1e.1; T21H8.1e.1; WBGene00011904. [Q94071-6]
DR EnsemblMetazoa; T21H8.1f.1; T21H8.1f.1; WBGene00011904. [Q94071-7]
DR EnsemblMetazoa; T21H8.1g.1; T21H8.1g.1; WBGene00011904. [Q94071-8]
DR EnsemblMetazoa; T21H8.1h.1; T21H8.1h.1; WBGene00011904. [Q94071-1]
DR EnsemblMetazoa; T21H8.1i.1; T21H8.1i.1; WBGene00011904. [Q94071-9]
DR EnsemblMetazoa; T21H8.1j.1; T21H8.1j.1; WBGene00011904. [Q94071-10]
DR EnsemblMetazoa; T21H8.1k.1; T21H8.1k.1; WBGene00011904. [Q94071-11]
DR EnsemblMetazoa; T21H8.1k.2; T21H8.1k.2; WBGene00011904. [Q94071-11]
DR EnsemblMetazoa; T21H8.1l.1; T21H8.1l.1; WBGene00011904. [Q94071-12]
DR EnsemblMetazoa; T21H8.1m.1; T21H8.1m.1; WBGene00011904. [Q94071-13]
DR EnsemblMetazoa; T21H8.1n.1; T21H8.1n.1; WBGene00011904. [Q94071-14]
DR EnsemblMetazoa; T21H8.1o.1; T21H8.1o.1; WBGene00011904. [Q94071-15]
DR EnsemblMetazoa; T21H8.1p.1; T21H8.1p.1; WBGene00011904. [Q94071-16]
DR EnsemblMetazoa; T21H8.1q.1; T21H8.1q.1; WBGene00011904. [Q94071-17]
DR EnsemblMetazoa; T21H8.1r.1; T21H8.1r.1; WBGene00011904. [Q94071-18]
DR EnsemblMetazoa; T21H8.1s.1; T21H8.1s.1; WBGene00011904. [Q94071-19]
DR GeneID; 181499; -.
DR KEGG; cel:CELE_T21H8.1; -.
DR UCSC; T21H8.1b.1; c. elegans.
DR UCSC; T21H8.5; c. elegans.
DR CTD; 181499; -.
DR WormBase; T21H8.1a; CE37412; WBGene00011904; hlb-1. [Q94071-2]
DR WormBase; T21H8.1b; CE41339; WBGene00011904; hlb-1. [Q94071-3]
DR WormBase; T21H8.1c; CE51474; WBGene00011904; hlb-1. [Q94071-4]
DR WormBase; T21H8.1d; CE51489; WBGene00011904; hlb-1. [Q94071-5]
DR WormBase; T21H8.1e; CE51430; WBGene00011904; hlb-1. [Q94071-6]
DR WormBase; T21H8.1f; CE51357; WBGene00011904; hlb-1. [Q94071-7]
DR WormBase; T21H8.1g; CE51523; WBGene00011904; hlb-1. [Q94071-8]
DR WormBase; T21H8.1h; CE51532; WBGene00011904; hlb-1. [Q94071-1]
DR WormBase; T21H8.1i; CE51461; WBGene00011904; hlb-1. [Q94071-9]
DR WormBase; T21H8.1j; CE51332; WBGene00011904; hlb-1. [Q94071-10]
DR WormBase; T21H8.1k; CE51249; WBGene00011904; hlb-1. [Q94071-11]
DR WormBase; T21H8.1l; CE51262; WBGene00011904; hlb-1. [Q94071-12]
DR WormBase; T21H8.1m; CE51507; WBGene00011904; hlb-1. [Q94071-13]
DR WormBase; T21H8.1n; CE51376; WBGene00011904; hlb-1. [Q94071-14]
DR WormBase; T21H8.1o; CE51301; WBGene00011904; hlb-1. [Q94071-15]
DR WormBase; T21H8.1p; CE18956; WBGene00011904; hlb-1. [Q94071-16]
DR WormBase; T21H8.1q; CE51549; WBGene00011904; hlb-1. [Q94071-17]
DR WormBase; T21H8.1r; CE51423; WBGene00011904; hlb-1. [Q94071-18]
DR WormBase; T21H8.1s; CE51350; WBGene00011904; hlb-1. [Q94071-19]
DR eggNOG; ENOG502TGDQ; Eukaryota.
DR eggNOG; KOG1899; Eukaryota.
DR GeneTree; ENSGT01050000244951; -.
DR HOGENOM; CLU_1526552_0_0_1; -.
DR InParanoid; Q94071; -.
DR OMA; QWILSGQ; -.
DR OrthoDB; 558442at2759; -.
DR Reactome; R-CEL-388844; Receptor-type tyrosine-protein phosphatases.
DR PRO; PR:Q94071; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00011904; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0048786; C:presynaptic active zone; IBA:GO_Central.
DR GO; GO:0007528; P:neuromuscular junction development; IMP:WormBase.
DR GO; GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
DR GO; GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.
DR GO; GO:0000003; P:reproduction; IMP:WormBase.
DR GO; GO:0050808; P:synapse organization; IBA:GO_Central.
DR CDD; cd09563; SAM_liprin-beta1_2_repeat1; 1.
DR CDD; cd09566; SAM_liprin-beta1_2_repeat2; 1.
DR CDD; cd09569; SAM_liprin-beta1_2_repeat3; 1.
DR Gene3D; 1.10.150.50; -; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR030444; Liprin-beta.
DR InterPro; IPR037617; Liprin-beta_SAM_rpt_1.
DR InterPro; IPR037618; Liprin-beta_SAM_rpt_2.
DR InterPro; IPR037619; Liprin-beta_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; PTHR12587; 1.
DR PANTHER; PTHR12587:SF14; PTHR12587:SF14; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SSF47769; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1004
FT /note="Liprin-beta homolog"
FT /id="PRO_0000191039"
FT DOMAIN 698..762
FT /note="SAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 770..833
FT /note="SAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 858..930
FT /note="SAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 50..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 280..328
FT /evidence="ECO:0000255"
FT COILED 364..396
FT /evidence="ECO:0000255"
FT COMPBIAS 50..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..321
FT /note="Missing (in isoform e and isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_060300"
FT VAR_SEQ 1..200
FT /note="MVYSSSSMSNTNIRRRSVPITIQKSRMDGFAEANQLLSSALEQLDDIIRNGN
FT STSRSTTTIGSAGPTPIIKKSFRDLLPPPPALRSTFSPRIMENGHSNLAHKQHINDDID
FT NGNADDERSSREINRQWISTDWKHRTDLGSDGSSGVESPPSDLPTSSSSLFSPPRVYQE
FT FVKAIDEQTMTERPDLETRLKIMQWVAGRT -> MAQRRAKSK (in isoform r
FT and isoform s)"
FT /evidence="ECO:0000305"
FT /id="VSP_060301"
FT VAR_SEQ 1..179
FT /note="Missing (in isoform m and isoform n)"
FT /evidence="ECO:0000305"
FT /id="VSP_060302"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform k, isoform l and isoform q)"
FT /evidence="ECO:0000305"
FT /id="VSP_060303"
FT VAR_SEQ 1..77
FT /note="MVYSSSSMSNTNIRRRSVPITIQKSRMDGFAEANQLLSSALEQLDDIIRNGN
FT STSRSTTTIGSAGPTPIIKKSFRDL -> MYSRHSISDAYGAVCILPEDTLTVSSSQNS
FT HIDAFAALVDRERDSSRSSGSGNIFKDNGSIKRRQALPYVTHYSDSGFGSAPSAGSSCS
FT Y (in isoform a, isoform b, isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_060304"
FT VAR_SEQ 1..26
FT /note="Missing (in isoform i, isoform j and isoform p)"
FT /evidence="ECO:0000305"
FT /id="VSP_060305"
FT VAR_SEQ 83..200
FT /note="ALRSTFSPRIMENGHSNLAHKQHINDDIDNGNADDERSSREINRQWISTDWK
FT HRTDLGSDGSSGVESPPSDLPTSSSSLFSPPRVYQEFVKAIDEQTMTERPDLETRLKIM
FT QWVAGRT -> PYRMRGSGGLSSKPQHKIHRSLSDSKYTASLMTTGVPTLPLLSMTPFN
FT QLQSRDARGASWISL (in isoform a, isoform b, isoform c and
FT isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_060306"
FT VAR_SEQ 201..202
FT /note="SP -> VS (in isoform o, isoform p and isoform q)"
FT /evidence="ECO:0000305"
FT /id="VSP_060307"
FT VAR_SEQ 203..1004
FT /note="Missing (in isoform o, isoform p and isoform q)"
FT /evidence="ECO:0000305"
FT /id="VSP_060308"
FT VAR_SEQ 273..319
FT /note="Missing (in isoform c and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_060309"
FT VAR_SEQ 569..610
FT /note="Missing (in isoform a, isoform c, isoform e, isoform
FT g, isoform i, isoform k, isoform m and isoform r)"
FT /evidence="ECO:0000305"
FT /id="VSP_060310"
SQ SEQUENCE 1004 AA; 112712 MW; A8F83DF79677EA29 CRC64;
MVYSSSSMSN TNIRRRSVPI TIQKSRMDGF AEANQLLSSA LEQLDDIIRN GNSTSRSTTT
IGSAGPTPII KKSFRDLLPP PPALRSTFSP RIMENGHSNL AHKQHINDDI DNGNADDERS
SREINRQWIS TDWKHRTDLG SDGSSGVESP PSDLPTSSSS LFSPPRVYQE FVKAIDEQTM
TERPDLETRL KIMQWVAGRT SPSPSMSTVS CPEYPELQDK LHRLAMARDS LQLQVSVLSE
QVGAQKEKIK DLETVIALKR NNLTSTEELL QDKYHRIDEC QELESKKMDL LAEVSSLKLR
YATLEREKNE TEKKLRLSQN EMDHVNQSMH GMVVQQQLAH HTNGHSSGGY MSPLREHRSE
KNDDEMSQLR TAVQRLMADN EHKSLQINTL RNALDEQMRS RSQQEDFYAS QRNYTDNFDV
NAQIRRILMD EPSDSMSHST SFPVSLSSTT SNGKGPRSTV QSSSSYNSSL SAVSPQHNWS
SAGAGTPRQL HPIGGNQRVN NITSAQYCSP SPPAARQLAA ELDELRRNGN EGANHNYSSA
SLPRGVGKAS STLTLPSKKL SVASGTSVGE LGGSMSSVAQ PTPKRNYRAQ MNRWINEKLR
RKRAVSAPNL VESDDEIARG RNLNNATSQS NLKNFSRERT RSSLRNIFSK LTRSTSQDQS
NSFRRGSAAR STSTARLGST NHLGTVSKRP PLSQFVDWRS EQLADWIAEI GYPQYMNEVS
RHVRSGRHFL NMSMNEYEGV LNIKNPVHRK RVAILLRRIE EDIMEPANKW DVHQTLRWLD
DIGLPQYKDV FAENVVDGPL LLSLTANDAV EMKVVNAHHY ATLARSIQFL KKADFRFNAM
EKLIDQNIVE KYPCPDVVVR WTHSATCEWL RKIDLAEFTQ NLLFAGVPGA LMIYEPSFTA
ESLAEILQMP PHKTLLRRHL TSHFNQLLGP KIIADKRDFL AAGNYPQISP TGRVKVVKKG
FSLTRKKAKN EICLEPEELL CPQVLVHKYP TGAGDNSSFE SSNV
