LIPJ_HUMAN
ID LIPJ_HUMAN Reviewed; 366 AA.
AC Q5W064; A8MT98; Q0P671;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Lipase member J;
DE EC=3.1.1.-;
DE AltName: Full=Lipase-like abhydrolase domain-containing protein 1;
GN Name=LIPJ; Synonyms=LIPL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-210.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL139406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031219; AAH31219.1; -; mRNA.
DR CCDS; CCDS31240.1; -.
DR RefSeq; NP_001010939.2; NM_001010939.2.
DR RefSeq; XP_006717698.1; XM_006717635.2.
DR RefSeq; XP_011537616.1; XM_011539314.2.
DR RefSeq; XP_011537617.1; XM_011539315.2.
DR AlphaFoldDB; Q5W064; -.
DR SMR; Q5W064; -.
DR STRING; 9606.ENSP00000361007; -.
DR ESTHER; human-LIPJ; Acidic_Lipase.
DR MEROPS; S33.020; -.
DR GlyConnect; 1458; 3 N-Linked glycans (1 site).
DR GlyGen; Q5W064; 1 site, 3 N-linked glycans (1 site).
DR iPTMnet; Q5W064; -.
DR PhosphoSitePlus; Q5W064; -.
DR BioMuta; LIPJ; -.
DR DMDM; 317373431; -.
DR MassIVE; Q5W064; -.
DR PaxDb; Q5W064; -.
DR PeptideAtlas; Q5W064; -.
DR PRIDE; Q5W064; -.
DR Antibodypedia; 30190; 83 antibodies from 15 providers.
DR DNASU; 142910; -.
DR Ensembl; ENST00000371939.7; ENSP00000361007.3; ENSG00000204022.9.
DR GeneID; 142910; -.
DR KEGG; hsa:142910; -.
DR MANE-Select; ENST00000371939.7; ENSP00000361007.3; NM_001010939.3; NP_001010939.2.
DR UCSC; uc001kff.3; human.
DR CTD; 142910; -.
DR DisGeNET; 142910; -.
DR GeneCards; LIPJ; -.
DR HGNC; HGNC:21773; LIPJ.
DR HPA; ENSG00000204022; Tissue enriched (testis).
DR MIM; 613921; gene.
DR neXtProt; NX_Q5W064; -.
DR OpenTargets; ENSG00000204022; -.
DR PharmGKB; PA162394099; -.
DR VEuPathDB; HostDB:ENSG00000204022; -.
DR eggNOG; KOG2624; Eukaryota.
DR GeneTree; ENSGT00940000163386; -.
DR HOGENOM; CLU_010974_0_0_1; -.
DR InParanoid; Q5W064; -.
DR OMA; PHGLGME; -.
DR OrthoDB; 651396at2759; -.
DR PhylomeDB; Q5W064; -.
DR TreeFam; TF315485; -.
DR PathwayCommons; Q5W064; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 142910; 12 hits in 1036 CRISPR screens.
DR GenomeRNAi; 142910; -.
DR Pharos; Q5W064; Tbio.
DR PRO; PR:Q5W064; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5W064; protein.
DR Bgee; ENSG00000204022; Expressed in right testis and 92 other tissues.
DR ExpressionAtlas; Q5W064; baseline and differential.
DR Genevisible; Q5W064; HS.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT CHAIN 1..366
FT /note="Lipase member J"
FT /id="PRO_0000288970"
FT ACT_SITE 141
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 312
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT ACT_SITE 341
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT VARIANT 210
FT /note="I -> V (in dbSNP:rs1409136)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032543"
SQ SEQUENCE 366 AA; 42388 MW; 0019AE513B75DD7A CRC64;
MNISQIISYW GYPDEEYDIV TEDGYILGLY RIPYWRTDNN KNLAQRVVVY LQHGLLTSAS
SWISNLPNNS LGFILADAGY DVWMGNSRGN TWSRKHLYLE TSSKEFWAFS FDEMAKYDLP
ASIDFTVKQT RQEEIFYVGH SQGTTIGFIT FSTISKIAER IKIFFALAPV FSTKYLKSPL
IRMTYKWKSI VMAFSGNKDF LPKTSFKKFI GSKLCPLQIF DKICLNILFM MFGYDPKNLN
MSRLDVYFSH NPAGTSVQNM LHWSQLLNST HLKAYDWGSP DLNLVHYNQT TSPLYNMTNM
NVATAIWNGK SDLLADPEDV NILHSEITNH IYYKTISYYN HIDSLFGLDV YDQVYHEIID
IIQDNL
