ID   LIPM_NEIMA              Reviewed;         704 AA.
AC   P57037; A1IP43;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Capsule polysaccharide modification protein LipA;
GN   Name=lipA; OrderedLocusNames=NMA0186;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- FUNCTION: Involved in the phospholipid modification of the capsular
CC       polysaccharide, a strong requirement for its translocation to the cell
CC       surface.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
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DR   EMBL; AL157959; CAM07501.1; -; Genomic_DNA.
DR   PIR; H82012; H82012.
DR   RefSeq; WP_002246741.1; NC_003116.1.
DR   AlphaFoldDB; P57037; -.
DR   SMR; P57037; -.
DR   EnsemblBacteria; CAM07501; CAM07501; NMA0186.
DR   KEGG; nma:NMA0186; -.
DR   HOGENOM; CLU_025998_0_0_4; -.
DR   OMA; IYIKIHP; -.
DR   BioCyc; NMEN122587:NMA_RS00960-MON; -.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007833; Capsule_polysaccharide_synth.
DR   Pfam; PF05159; Capsule_synth; 3.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Membrane; Polysaccharide transport;
KW   Sugar transport; Transport.
FT   CHAIN           1..704
FT                   /note="Capsule polysaccharide modification protein LipA"
FT                   /id="PRO_0000084438"
SQ   SEQUENCE   704 AA;  79566 MW;  2E1C5DE665D9BB61 CRC64;
     MFLFSDGLQS INNNNRRKRI VKNAYIPSRG IRKIPHLSTL LPEFHIYKDG KGAEAVVGWG
     LRPTTHKARA FATEHQLPFI ALEDGFLRSL GLGVSGYPPY SIVYDDIGIY YDTTRPSRLE
     QLILAADTMP SETLAQARQA MDFILQHHLS KYNHAPELSD DHPLRSPSKS ETVLIIDQTF
     GDMAIQYGGA DASTFELMFQ TALNENPQAD IWVKTHPDVL CGKKQGYLTQ LVQQHRVHLL
     AEDINPISLL QNVDKVYCVT SQMGFEALLC GKPLTTFGLP WYAGWGVSDD RHPKIGSLIQ
     TQRRAPRNLL QLFAAAYLQY SRYLNPNTGE AGSLFDVIDY LATVKRKNDK LRGELYCVGM
     SLWKRAVAKP FFNVPSCRLK FISSTQKLAR VKLSDDARIL AWGNGKEAIV RFAEQHHIPL
     LRMEDGFIRS VGLGSNLVPP LSLVTDDMSI YFNAETPSRL EYILQNQNFD DQDFQTALKL
     QKMLTENHIS KYNVGSSDFT APSTDKTVIL VPGQVEDDAS IRYGSPQIYR NLDLLRTVRE
     RNPNAYIIYK PHPDVVSGNR IGHISPDDAA RYADQTAEQA DILTCLQYAD EIHTMTSLTG
     FEALLRGKKV SCYGLPFYAG WGLTQDLLPI PRRSRRLELW QLVAGTLIYY PDYIHPKTHQ
     AINAETAAQI LIRQKNMQKN NNGLHRGCFA KKLGKIKQLY RSFK