ID   LIPM_NEIMB              Reviewed;         704 AA.
AC   Q05013;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Capsule polysaccharide modification protein LipA;
GN   Name=lipA; OrderedLocusNames=NMB0082;
OS   Neisseria meningitidis serogroup B (strain MC58).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC58;
RX   PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA   Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA   Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA   Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA   Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA   Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA   Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA   Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA   Moxon E.R., Rappuoli R., Venter J.C.;
RT   "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT   MC58.";
RL   Science 287:1809-1815(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 184-704.
RC   STRAIN=B1940 / Serogroup B;
RX   PubMed=8326861; DOI=10.1111/j.1365-2958.1993.tb01592.x;
RA   Frosch M., Mueller A.;
RT   "Phospholipid substitution of capsular polysaccharides and mechanisms of
RT   capsule formation in Neisseria meningitidis.";
RL   Mol. Microbiol. 8:483-493(1993).
CC   -!- FUNCTION: Involved in the phospholipid modification of the capsular
CC       polysaccharide, a strong requirement for its translocation to the cell
CC       surface.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=Z13995; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE002098; AAF40546.1; -; Genomic_DNA.
DR   EMBL; Z13995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; D81240; D81240.
DR   PIR; S32879; S32879.
DR   RefSeq; NP_273145.1; NC_003112.2.
DR   RefSeq; WP_002224756.1; NC_003112.2.
DR   AlphaFoldDB; Q05013; -.
DR   SMR; Q05013; -.
DR   STRING; 122586.NMB0082; -.
DR   PaxDb; Q05013; -.
DR   EnsemblBacteria; AAF40546; AAF40546; NMB0082.
DR   KEGG; nme:NMB0082; -.
DR   PATRIC; fig|122586.8.peg.117; -.
DR   HOGENOM; CLU_025998_0_0_4; -.
DR   OMA; IYIKIHP; -.
DR   Proteomes; UP000000425; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007833; Capsule_polysaccharide_synth.
DR   Pfam; PF05159; Capsule_synth; 3.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Membrane; Polysaccharide transport;
KW   Reference proteome; Sugar transport; Transport.
FT   CHAIN           1..704
FT                   /note="Capsule polysaccharide modification protein LipA"
FT                   /id="PRO_0000084439"
FT   CONFLICT        238
FT                   /note="H -> N (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        253
FT                   /note="V -> I (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294..297
FT                   /note="EINR -> KIDS (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        306
FT                   /note="T -> P (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        316
FT                   /note="A -> R (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="A -> R (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390
FT                   /note="R -> G (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        449
FT                   /note="S -> G (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        456
FT                   /note="T -> A (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        462
FT                   /note="Y -> H (in Ref. 2; Z13995)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   704 AA;  79606 MW;  2909C40642CD326A CRC64;
     MFLFSDGLQS INNNNRRKRI VKNAYIPSRG IRKIPHLSTL LPEFHICKDG KEAEAVVGWG
     LRPTTHKARA FAAEHQLPFI ALEDGFLRSL GLGVAGYPPY SIVYDDIGIY YDTTRPSRLE
     QLILAADTMP SETLAQAQQA MDFILQHHLS KYNHAPELSD DHPLRSPSKP ETVLIIDQTF
     GDMAIQYGGA DASTFELMFQ TALNENPQAD IWVKTHPDVL CGKKQGYLTQ LAQQHRVHLL
     AEDINPISLL QNVDKVYCVT SQMGFEALLC GKPLTTFGLP WYAGWGVSDD RHPEINRLVQ
     TQRRATRNLL QLFAAAYLQY SRYLNPNTGE AGSLFDVIDY LATVKRKNDK LRGELYCVGM
     SLWKRAVAKP FFNVPSCRLK FISSTQKLAR VKLSDDARIL AWGNGKEAIV RFAEQHHIPL
     LRMEDGFIRS VGLGSNLVPP LSLVTDDMSI YFNAETPSRL EYILQNQNFD DQDFQTALKL
     QKMLTENHIS KYNVGSSDFT APSTDKTVIL VPGQVEDDAS IRYGSPQIYR NLDLLRTVRE
     RNPNAYIIYK PHPDVVSGNR IGHISPEDAA RYADQTAEQA DILTCLQYAD EIHTMTSLTG
     FEALLRGKKV SCYGLPFYAG WGLTQDLLPI PRRSRRLELW QLIAGTLIHY PDYIHPETHQ
     AINAETAAQI LIRQKNMQKN NNGLHRGCFA KKLGKIKQLY RSFK