ID   LIPO_BACSU              Reviewed;         502 AA.
AC   P37966;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Lipoprotein LipO;
DE   AltName: Full=Lipoprotein LplA;
DE   Flags: Precursor;
GN   Name=lipO; Synonyms=lplA; OrderedLocusNames=BSU07100;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PALMITOYLATION AT CYS-22.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=7921237; DOI=10.1099/13500872-140-8-1839;
RA   Gomez A., Ramon D., Sanz P.;
RT   "The Bacillus subtilis lipoprotein LplA causes cell lysis when expressed in
RT   Escherichia coli.";
RL   Microbiology 140:1839-1845(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; L03376; AAC36913.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12529.1; -; Genomic_DNA.
DR   PIR; I39876; I39876.
DR   RefSeq; NP_388591.1; NC_000964.3.
DR   RefSeq; WP_003244341.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; P37966; -.
DR   SMR; P37966; -.
DR   STRING; 224308.BSU07100; -.
DR   PaxDb; P37966; -.
DR   PRIDE; P37966; -.
DR   EnsemblBacteria; CAB12529; CAB12529; BSU_07100.
DR   GeneID; 936079; -.
DR   KEGG; bsu:BSU07100; -.
DR   PATRIC; fig|224308.179.peg.770; -.
DR   eggNOG; COG1653; Bacteria.
DR   InParanoid; P37966; -.
DR   OMA; KGAQLDN; -.
DR   PhylomeDB; P37966; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006059; SBP.
DR   Pfam; PF01547; SBP_bac_1; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           22..502
FT                   /note="Lipoprotein LipO"
FT                   /id="PRO_0000018179"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305|PubMed:7921237"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   502 AA;  56223 MW;  1FDC5F4108BF004B CRC64;
     MKIRMRKKWM ALPLAAMMIA GCSHSETSNS ASGSKDTIKI MAPLLSPESP SDKSPSLKAL
     EKYTGKEIKV TWVPDSSYND KFNIVMASGE MPHAIVIKDK SAGFIKSVKA GAFWELSPYL
     KDYKNLSQAD EKILKNSSVN GEVYGIYRTR DLIRACMIIR TDWLKNVGLD MPETLDDFYE
     VLKAFKEKDP DGNGKDDTYG MVVPKWMGLG NGSPWDVLQI WFGAPNRYGV ENGKLIPDFT
     TKEYMDALTF FKKLYDEGLI NKDFAVMDSA KWNDPVVKGK AGVIVDTGSR ASQIQSAMEE
     ADESNKDIID IVGSLEGPNG KRTFPTSGYS GMITIPKSSV KTEKELKEVL SFLDKMNDKE
     AQILTNNGVK GRNYELKDGV FTSLEKNNKS LLYEHEGLAQ FSMSIPKSEY YIEDQKTKLF
     QHRKDIITEG EKIAVFNPAE SLVSDVYTQK GAQLDNIILD ARTQFIIGEI DEKGFDDAVE
     LWKKSGGNEL MKDLNKLYQS SK