LIPR3_HUMAN
ID LIPR3_HUMAN Reviewed; 467 AA.
AC Q17RR3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Pancreatic lipase-related protein 3;
DE Short=PL-RP3;
DE EC=3.1.1.3;
DE Flags: Precursor;
GN Name=PNLIPRP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-381 AND GLY-382.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19640199;
RA Saelee P., Wongkham S., Puapairoj A., Khuntikeo N., Petmitr S.,
RA Chariyalertsak S., Sumethchotimaytha W., Karalak A.;
RT "Novel PNLIPRP3 and DOCK8 gene expression and prognostic implications of
RT DNA loss on chromosome 10q25.3 in hepatocellular carcinoma.";
RL Asian Pac. J. Cancer Prev. 10:501-506(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid +
CC H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Overexpressed in hepatocellular carcinoma.
CC {ECO:0000269|PubMed:19640199}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000305}.
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DR EMBL; AC011328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117224; AAI17225.1; -; mRNA.
DR CCDS; CCDS31292.1; -.
DR RefSeq; NP_001011709.2; NM_001011709.2.
DR AlphaFoldDB; Q17RR3; -.
DR SMR; Q17RR3; -.
DR STRING; 9606.ENSP00000358232; -.
DR ESTHER; human-PNLIPRP3; Pancreatic_lipase.
DR GlyGen; Q17RR3; 3 sites.
DR iPTMnet; Q17RR3; -.
DR PhosphoSitePlus; Q17RR3; -.
DR BioMuta; PNLIPRP3; -.
DR DMDM; 269849614; -.
DR EPD; Q17RR3; -.
DR jPOST; Q17RR3; -.
DR MassIVE; Q17RR3; -.
DR PaxDb; Q17RR3; -.
DR PeptideAtlas; Q17RR3; -.
DR PRIDE; Q17RR3; -.
DR Antibodypedia; 52438; 113 antibodies from 15 providers.
DR DNASU; 119548; -.
DR Ensembl; ENST00000369230.4; ENSP00000358232.3; ENSG00000203837.5.
DR GeneID; 119548; -.
DR KEGG; hsa:119548; -.
DR MANE-Select; ENST00000369230.4; ENSP00000358232.3; NM_001011709.3; NP_001011709.2.
DR UCSC; uc001lcl.5; human.
DR CTD; 119548; -.
DR DisGeNET; 119548; -.
DR GeneCards; PNLIPRP3; -.
DR HGNC; HGNC:23492; PNLIPRP3.
DR HPA; ENSG00000203837; Tissue enhanced (breast, skin).
DR neXtProt; NX_Q17RR3; -.
DR OpenTargets; ENSG00000203837; -.
DR PharmGKB; PA134954941; -.
DR VEuPathDB; HostDB:ENSG00000203837; -.
DR eggNOG; ENOG502SHK7; Eukaryota.
DR GeneTree; ENSGT00940000163197; -.
DR HOGENOM; CLU_027171_0_2_1; -.
DR InParanoid; Q17RR3; -.
DR OMA; NRSYYFL; -.
DR OrthoDB; 534956at2759; -.
DR PhylomeDB; Q17RR3; -.
DR TreeFam; TF324997; -.
DR PathwayCommons; Q17RR3; -.
DR Reactome; R-HSA-192456; Digestion of dietary lipid.
DR SignaLink; Q17RR3; -.
DR BioGRID-ORCS; 119548; 6 hits in 1064 CRISPR screens.
DR ChiTaRS; PNLIPRP3; human.
DR GenomeRNAi; 119548; -.
DR Pharos; Q17RR3; Tdark.
DR PRO; PR:Q17RR3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q17RR3; protein.
DR Bgee; ENSG00000203837; Expressed in upper leg skin and 66 other tissues.
DR Genevisible; Q17RR3; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016298; F:lipase activity; IBA:GO_Central.
DR GO; GO:0004806; F:triglyceride lipase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IBA:GO_Central.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR002331; Lipase_panc.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; PTHR11610; 1.
DR Pfam; PF00151; Lipase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00823; PANCLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF49723; SSF49723; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hydrolase; Lipid degradation;
KW Lipid metabolism; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..467
FT /note="Pancreatic lipase-related protein 3"
FT /id="PRO_0000286602"
FT DOMAIN 355..467
FT /note="PLAT"
FT ACT_SITE 168
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 191
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT ACT_SITE 279
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 21..27
FT /evidence="ECO:0000250"
FT DISULFID 107..118
FT /evidence="ECO:0000250"
FT DISULFID 252..277
FT /evidence="ECO:0000250"
FT DISULFID 301..312
FT /evidence="ECO:0000250"
FT DISULFID 315..320
FT /evidence="ECO:0000250"
FT DISULFID 451..467
FT /evidence="ECO:0000250"
FT VARIANT 2
FT /note="L -> F (in dbSNP:rs10885929)"
FT /id="VAR_032141"
FT VARIANT 332
FT /note="F -> L (in dbSNP:rs7077408)"
FT /id="VAR_032142"
FT VARIANT 381
FT /note="V -> I (in dbSNP:rs10736251)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060285"
FT VARIANT 382
FT /note="R -> G (in dbSNP:rs1897519)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060286"
FT VARIANT 450
FT /note="F -> Y (in dbSNP:rs2116286)"
FT /id="VAR_032143"
SQ SEQUENCE 467 AA; 52254 MW; F383E516278D1FC2 CRC64;
MLGIWIVAFL FFGTSRGKEV CYERLGCFKD GLPWTRTFST ELVGLPWSPE KINTRFLLYT
IHNPNAYQEI SAVNSSTIQA SYFGTDKITR INIAGWKTDG KWQRDMCNVL LQLEDINCIN
LDWINGSREY IHAVNNLRVV GAEVAYFIDV LMKKFEYSPS KVHLIGHSLG AHLAGEAGSR
IPGLGRITGL DPAGPFFHNT PKEVRLDPSD ANFVDVIHTN AARILFELGV GTIDACGHLD
FYPNGGKHMP GCEDLITPLL KFNFNAYKKE MASFFDCNHA RSYQFYAESI LNPDAFIAYP
CRSYTSFKAG NCFFCSKEGC PTMGHFADRF HFKNMKTNGS HYFLNTGSLS PFARWRHKLS
VKLSGSEVTQ GTVFLRVGGA VRKTGEFAIV SGKLEPGMTY TKLIDADVNV GNITSVQFIW
KKHLFEDSQN KLGAEMVINT SGKYGYKSTF CSQDIMGPNI LQNLKPC
