ID   LIPZ_MYCTU              Reviewed;         288 AA.
AC   P9WLR1; L0TAJ1; Q50599;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Putative hydrolase LipZ {ECO:0000303|PubMed:16354661};
DE            EC=3.-.-.- {ECO:0000305};
GN   Name=lipZ {ECO:0000303|PubMed:16354661}; OrderedLocusNames=Rv1834;
GN   ORFNames=MTCY1A11.09c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NOMENCLATURE.
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RX   PubMed=16354661; DOI=10.1074/jbc.m505556200;
RA   Deb C., Daniel J., Sirakova T.D., Abomoelak B., Dubey V.S.,
RA   Kolattukudy P.E.;
RT   "A novel lipase belonging to the hormone-sensitive lipase family induced
RT   under starvation to utilize stored triacylglycerol in Mycobacterium
RT   tuberculosis.";
RL   J. Biol. Chem. 281:3866-3875(2006).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44600.1; -; Genomic_DNA.
DR   PIR; C70722; C70722.
DR   RefSeq; NP_216350.1; NC_000962.3.
DR   RefSeq; WP_003409255.1; NZ_NVQJ01000013.1.
DR   AlphaFoldDB; P9WLR1; -.
DR   SMR; P9WLR1; -.
DR   STRING; 83332.Rv1834; -.
DR   ESTHER; myctu-Y1834; MEST-like.
DR   PaxDb; P9WLR1; -.
DR   DNASU; 888761; -.
DR   GeneID; 888761; -.
DR   KEGG; mtu:Rv1834; -.
DR   TubercuList; Rv1834; -.
DR   eggNOG; COG0596; Bacteria.
DR   OMA; CDMLGFG; -.
DR   PhylomeDB; P9WLR1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR000639; Epox_hydrolase-like.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   PRINTS; PR00412; EPOXHYDRLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..288
FT                   /note="Putative hydrolase LipZ"
FT                   /id="PRO_0000103907"
SQ   SEQUENCE   288 AA;  31676 MW;  F9A7879B40454363 CRC64;
     MTSPSVREWR DGGRWLPTAV GKVFVRSGPG DTPTMLLLHG YPSSSFDFRA VIPHLTGQAW
     VTMDFLGFGL SDKPRPHRYS LLEQAHLVET VVAHTVTGAV VVLAHDMGTS VTTELLARDL
     DGRLPFDLRR AVLSNGSVIL ERASLRPIQK VLRSPLGPVA ARLVSRGGFT RGFGRIFSPA
     HPLSAQEAQA QWELLCYNDG NRIPHLLISY LDERIRHAQR WHGAVRDWPK PLGFVWGLDD
     PVATTNVLNG LRELRPSAAV VELPGLGHYP QVEAPKAYAE AALSLLVD