ID   LIR3_CAEEL              Reviewed;         284 AA.
AC   O17862;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Transcription factor lir-3 {ECO:0000305};
DE   AltName: Full=Lin-26-related protein 3 {ECO:0000312|WormBase:F37H8.1};
DE   AltName: Full=Modifier of aggregation protein 2 {ECO:0000303|PubMed:28306505};
GN   Name=lir-3 {ECO:0000303|PubMed:28306505, ECO:0000312|WormBase:F37H8.1};
GN   Synonyms=moag-2 {ECO:0000303|PubMed:28306505};
GN   ORFNames=F37H8.1 {ECO:0000312|WormBase:F37H8.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=22087002; DOI=10.1073/pnas.1111684108;
RA   Topalidou I., Chalfie M.;
RT   "Shared gene expression in distinct neurons expressing common selector
RT   genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:19258-19263(2011).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28306505; DOI=10.1016/j.molcel.2017.02.022;
RA   Sin O., de Jong T., Mata-Cabana A., Kudron M., Zaini M.A., Aprile F.A.,
RA   Seinstra R.I., Stroo E., Prins R.W., Martineau C.N., Wang H.H.,
RA   Hogewerf W., Steinhof A., Wanker E.E., Vendruscolo M., Calkhoven C.F.,
RA   Reinke V., Guryev V., Nollen E.A.;
RT   "Identification of an RNA polymerase III regulator linked to disease-
RT   associated protein aggregation.";
RL   Mol. Cell 65:1096-1108(2017).
CC   -!- FUNCTION: Positively regulates the RNA polymerase III-associated
CC       transcription of small non-coding RNAs. {ECO:0000269|PubMed:28306505}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28306505}.
CC       Note=Mislocalizes to the cytosol in the presence of polyglutamine.
CC       {ECO:0000269|PubMed:28306505}.
CC   -!- TISSUE SPECIFICITY: Expressed in FLP neurons.
CC       {ECO:0000269|PubMed:22087002}.
CC   -!- MISCELLANEOUS: In the presence of polyglutamine, mislocalizes to the
CC       cytosol and loses its transcriptional regulation activity, but is able
CC       to promote protein aggregation. {ECO:0000269|PubMed:28306505}.
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DR   EMBL; BX284602; CAB04346.1; -; Genomic_DNA.
DR   PIR; T21923; T21923.
DR   RefSeq; NP_496395.1; NM_063994.4.
DR   AlphaFoldDB; O17862; -.
DR   IntAct; O17862; 8.
DR   STRING; 6239.F37H8.1; -.
DR   EPD; O17862; -.
DR   PaxDb; O17862; -.
DR   EnsemblMetazoa; F37H8.1.1; F37H8.1.1; WBGene00003046.
DR   GeneID; 174707; -.
DR   KEGG; cel:CELE_F37H8.1; -.
DR   UCSC; F37H8.1; c. elegans.
DR   CTD; 174707; -.
DR   WormBase; F37H8.1; CE15994; WBGene00003046; lir-3.
DR   eggNOG; ENOG502TGQ5; Eukaryota.
DR   GeneTree; ENSGT00970000196232; -.
DR   HOGENOM; CLU_980819_0_0_1; -.
DR   InParanoid; O17862; -.
DR   OMA; QMHVIAL; -.
DR   OrthoDB; 1363071at2759; -.
DR   PRO; PR:O17862; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003046; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..284
FT                   /note="Transcription factor lir-3"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000440578"
FT   ZN_FING         224..247
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          50..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  32495 MW;  5B593C991CF53FA7 CRC64;
     MDPKFLVVEI DSKERALQLV QVMLENGFAR FMLLDDLSRH PTLDRIQREE PRISRDELRE
     TASSPVTFET RHSPYPVHEQ KVLFPSFSQV SNSMVTSTGI RQEASSVGVG PIEDDDIVEE
     EEEEDIRLTS KPCVKRRYDH HAEEQEYRDQ LMSLLSGEPE IVPIGVNSND EPSGSNSDSA
     AKKAKSVGDY HECQLCGVRV KTPRSGRWNL QMHVIALHCV GRQYKCKQCD YLDYRKSTMR
     KHTVSQHGSD IPPHNITDNI MKAEWHAAMI KCFPEFAHRT GFLN