LIRA1_HUMAN
ID LIRA1_HUMAN Reviewed; 489 AA.
AC O75019; O75018; Q3MJA6;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Leukocyte immunoglobulin-like receptor subfamily A member 1;
DE AltName: Full=CD85 antigen-like family member I;
DE AltName: Full=Leukocyte immunoglobulin-like receptor 6;
DE Short=LIR-6;
DE AltName: CD_antigen=CD85i;
DE Flags: Precursor;
GN Name=LILRA1; Synonyms=LIR6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP VARIANTS GLY-12 AND PRO-220.
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=9548455;
RA Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.;
RT "A family of human lymphoid and myeloid Ig-like receptors, some of which
RT bind to MHC class I molecules.";
RL J. Immunol. 159:5192-5196(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as receptor for class I MHC antigens.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=LIR-6a;
CC IsoId=O75019-1; Sequence=Displayed;
CC Name=2; Synonyms=LIR-6b;
CC IsoId=O75019-2; Sequence=VSP_008454;
CC -!- TISSUE SPECIFICITY: Detected in monocytes and B-cells.
CC {ECO:0000269|PubMed:9548455}.
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DR EMBL; AF025529; AAB87663.1; -; mRNA.
DR EMBL; AF025530; AAB87664.1; -; mRNA.
DR EMBL; BC101514; AAI01515.1; -; mRNA.
DR CCDS; CCDS12901.1; -. [O75019-1]
DR CCDS; CCDS62802.1; -. [O75019-2]
DR RefSeq; NP_001265247.1; NM_001278318.1. [O75019-2]
DR RefSeq; NP_001265248.1; NM_001278319.1.
DR RefSeq; NP_006854.1; NM_006863.3. [O75019-1]
DR AlphaFoldDB; O75019; -.
DR SMR; O75019; -.
DR BioGRID; 116214; 1.
DR IntAct; O75019; 1.
DR STRING; 9606.ENSP00000251372; -.
DR GlyGen; O75019; 6 sites.
DR iPTMnet; O75019; -.
DR PhosphoSitePlus; O75019; -.
DR BioMuta; LILRA1; -.
DR MassIVE; O75019; -.
DR PaxDb; O75019; -.
DR PeptideAtlas; O75019; -.
DR PRIDE; O75019; -.
DR ProteomicsDB; 49694; -. [O75019-1]
DR ProteomicsDB; 49695; -. [O75019-2]
DR Antibodypedia; 46369; 199 antibodies from 24 providers.
DR DNASU; 11024; -.
DR Ensembl; ENST00000251372.8; ENSP00000251372.3; ENSG00000104974.12. [O75019-1]
DR Ensembl; ENST00000453777.1; ENSP00000413715.1; ENSG00000104974.12. [O75019-2]
DR Ensembl; ENST00000617170.4; ENSP00000477637.1; ENSG00000275525.5. [O75019-1]
DR Ensembl; ENST00000620606.4; ENSP00000478666.1; ENSG00000275525.5. [O75019-2]
DR Ensembl; ENST00000628480.1; ENSP00000487229.1; ENSG00000277398.5. [O75019-2]
DR Ensembl; ENST00000631007.1; ENSP00000487011.1; ENSG00000274935.5. [O75019-2]
DR GeneID; 11024; -.
DR KEGG; hsa:11024; -.
DR MANE-Select; ENST00000251372.8; ENSP00000251372.3; NM_006863.4; NP_006854.1.
DR UCSC; uc002qgh.4; human. [O75019-1]
DR CTD; 11024; -.
DR DisGeNET; 11024; -.
DR GeneCards; LILRA1; -.
DR HGNC; HGNC:6602; LILRA1.
DR HPA; ENSG00000104974; Tissue enriched (lymphoid).
DR MIM; 604810; gene.
DR neXtProt; NX_O75019; -.
DR OpenTargets; ENSG00000104974; -.
DR PharmGKB; PA30376; -.
DR VEuPathDB; HostDB:ENSG00000104974; -.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR GeneTree; ENSGT01000000214458; -.
DR HOGENOM; CLU_021100_1_4_1; -.
DR InParanoid; O75019; -.
DR OMA; NAYLLTH; -.
DR OrthoDB; 1000446at2759; -.
DR PhylomeDB; O75019; -.
DR TreeFam; TF336644; -.
DR PathwayCommons; O75019; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; O75019; -.
DR BioGRID-ORCS; 11024; 16 hits in 1027 CRISPR screens.
DR ChiTaRS; LILRA1; human.
DR GenomeRNAi; 11024; -.
DR Pharos; O75019; Tdark.
DR PRO; PR:O75019; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75019; protein.
DR Bgee; ENSG00000104974; Expressed in monocyte and 93 other tissues.
DR Genevisible; O75019; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003823; F:antigen binding; TAS:ProtInc.
DR GO; GO:0032396; F:inhibitory MHC class I receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; TAS:ProtInc.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF13895; Ig_2; 2.
DR PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Alternative splicing; Disulfide bond; Glycoprotein;
KW Immunity; Immunoglobulin domain; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..489
FT /note="Leukocyte immunoglobulin-like receptor subfamily A
FT member 1"
FT /id="PRO_0000014816"
FT TOPO_DOM 17..461
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..489
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..116
FT /note="Ig-like C2-type 1"
FT DOMAIN 119..224
FT /note="Ig-like C2-type 2"
FT DOMAIN 226..315
FT /note="Ig-like C2-type 3"
FT DOMAIN 326..415
FT /note="Ig-like C2-type 4"
FT REGION 425..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 281
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 341
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 431
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 448
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..98
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 145..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 157..167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 246..297
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 346..397
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 221..420
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9548455"
FT /id="VSP_008454"
FT VARIANT 12
FT /note="R -> G (in dbSNP:rs1974982)"
FT /evidence="ECO:0000269|PubMed:9548455"
FT /id="VAR_059396"
FT VARIANT 153
FT /note="S -> G (in dbSNP:rs10417589)"
FT /id="VAR_049886"
FT VARIANT 220
FT /note="L -> P (in dbSNP:rs373854)"
FT /evidence="ECO:0000269|PubMed:9548455"
FT /id="VAR_049887"
FT CONFLICT 5
FT /note="V -> L (in Ref. 1; AAB87663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 489 AA; 53275 MW; 44469FD4884EA068 CRC64;
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL
YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG
AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA
IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE
SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA
GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS
GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF
EAQHSQRSL
