LIRA6_HUMAN
ID LIRA6_HUMAN Reviewed; 481 AA.
AC Q6PI73;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Leukocyte immunoglobulin-like receptor subfamily A member 6;
DE AltName: Full=Immunoglobulin-like transcript 8;
DE Short=ILT-8;
DE AltName: Full=Leukocyte Ig-like receptor;
DE Flags: Precursor;
GN Name=LILRA6; Synonyms=ILT8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION IN THE LRC.
RX PubMed=10941842; DOI=10.1007/s002510000187;
RA Wende H., Volz A., Ziegler A.;
RT "Extensive gene duplications and a large inversion characterize the human
RT leukocyte receptor cluster.";
RL Immunogenetics 51:703-713(2000).
RN [4]
RP ERRATUM OF PUBMED:10941842.
RA Wende H., Volz A., Ziegler A.;
RL Immunogenetics 52:3-4(2001).
CC -!- FUNCTION: May act as receptor for class I MHC antigens. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PI73-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PI73-2; Sequence=VSP_038149, VSP_038150;
CC -!- MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present
CC on 19q13.4.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AC010492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041708; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q6PI73; -.
DR SMR; Q6PI73; -.
DR BioGRID; 116215; 18.
DR IntAct; Q6PI73; 1.
DR STRING; 9606.ENSP00000379651; -.
DR GlyGen; Q6PI73; 3 sites.
DR iPTMnet; Q6PI73; -.
DR PhosphoSitePlus; Q6PI73; -.
DR BioMuta; LILRA6; -.
DR DMDM; 152032558; -.
DR jPOST; Q6PI73; -.
DR MassIVE; Q6PI73; -.
DR PaxDb; Q6PI73; -.
DR PeptideAtlas; Q6PI73; -.
DR PRIDE; Q6PI73; -.
DR ProteomicsDB; 67141; -. [Q6PI73-1]
DR ProteomicsDB; 67142; -. [Q6PI73-2]
DR Antibodypedia; 58767; 90 antibodies from 13 providers.
DR DNASU; 79168; -.
DR Ensembl; ENST00000396365.6; ENSP00000379651.2; ENSG00000244482.10.
DR Ensembl; ENST00000430421.5; ENSP00000412929.1; ENSG00000244482.10.
DR Ensembl; ENST00000613333.4; ENSP00000478128.1; ENSG00000274148.5. [Q6PI73-2]
DR Ensembl; ENST00000614434.4; ENSP00000484617.1; ENSG00000275539.5. [Q6PI73-2]
DR Ensembl; ENST00000616720.4; ENSP00000478896.1; ENSG00000274148.5. [Q6PI73-2]
DR Ensembl; ENST00000621570.4; ENSP00000480300.1; ENSG00000274148.5. [Q6PI73-1]
DR UCSC; uc032ide.2; human. [Q6PI73-1]
DR GeneCards; LILRA6; -.
DR HGNC; HGNC:15495; LILRA6.
DR HPA; ENSG00000244482; Group enriched (lung, lymphoid tissue).
DR neXtProt; NX_Q6PI73; -.
DR PharmGKB; PA142671548; -.
DR VEuPathDB; HostDB:ENSG00000244482; -.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR HOGENOM; CLU_021100_7_0_1; -.
DR InParanoid; Q6PI73; -.
DR OrthoDB; 1000446at2759; -.
DR PhylomeDB; Q6PI73; -.
DR TreeFam; TF336644; -.
DR PathwayCommons; Q6PI73; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q6PI73; -.
DR Pharos; Q6PI73; Tbio.
DR PRO; PR:Q6PI73; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PI73; protein.
DR Bgee; ENSG00000244482; Expressed in blood and 92 other tissues.
DR ExpressionAtlas; Q6PI73; baseline and differential.
DR Genevisible; Q6PI73; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032396; F:inhibitory MHC class I receptor activity; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Alternative splicing; Disulfide bond; Glycoprotein;
KW Immunity; Immunoglobulin domain; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..481
FT /note="Leukocyte immunoglobulin-like receptor subfamily A
FT member 6"
FT /id="PRO_0000294367"
FT TOPO_DOM 24..447
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 469..481
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 225..314
FT /note="Ig-like C2-type 1"
FT DOMAIN 323..408
FT /note="Ig-like C2-type 2"
FT REGION 59..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 340
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..98
FT /evidence="ECO:0000250|UniProtKB:Q8NHL6"
FT DISULFID 144..196
FT /evidence="ECO:0000250|UniProtKB:Q8NHL6"
FT DISULFID 245..296
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 345..396
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 192..193
FT /note="WR -> RV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038149"
FT VAR_SEQ 194..481
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038150"
FT VARIANT 69
FT /note="L -> W (in dbSNP:rs620207)"
FT /id="VAR_033170"
FT VARIANT 149
FT /note="G -> R (in dbSNP:rs1052966)"
FT /id="VAR_033171"
FT VARIANT 288
FT /note="P -> R (in dbSNP:rs1052975)"
FT /id="VAR_033172"
FT VARIANT 400
FT /note="Y -> H (in dbSNP:rs8104206)"
FT /id="VAR_033173"
SQ SEQUENCE 481 AA; 52399 MW; 674640305171201F CRC64;
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSLEAQEYQL
DKEGSPEPLD RNNPLEPKNK ARFSIPSMTQ HHAGRYRCHY YSSAGWSEPS DPLELVMTGF
YNKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSGGFQAL
FPVGPVTPSH RWRFTCYYYY TNTPRVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS
LTLQCGSDVG YDRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSH GGQYRCYGAH
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSRGY FDTFLLTKEG
AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPHLLSFP SEPLELMVSG
HSGGSSLPPT GPPSTPASHA KDYTVENLIR MGMAGLVLVF LGILLFEAQH SQRNPQDAAG
R
