LIS11_PENRW
ID LIS11_PENRW Reviewed; 458 AA.
AC B6HP56;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Nuclear distribution protein nudF 1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=Lissencephaly-1 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE Short=LIS-1 1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=nudF-1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Synonyms=lis1-1 {ECO:0000255|HAMAP-Rule:MF_03141}; ORFNames=Pc22g02040;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. May enhance dynein-mediated
CC microtubule sliding by targeting dynein to the microtubule plus end.
CC Required for nuclear migration during vegetative growth as well as
CC development. Required for retrograde early endosome (EE) transport from
CC the hyphal tip. Required for localization of dynein to the mitotic
CC spindle poles. Recruits additional proteins to the dynein complex at
CC SPBs. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBUNIT: Self-associates. Interacts with nudE and dynein.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus ends of
CC microtubules at the hyphal tip and the mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; AM920437; CAP97492.1; -; Genomic_DNA.
DR RefSeq; XP_002564248.1; XM_002564202.1.
DR AlphaFoldDB; B6HP56; -.
DR SMR; B6HP56; -.
DR STRING; 1108849.XP_002564248.1; -.
DR EnsemblFungi; CAP97492; CAP97492; PCH_Pc22g02040.
DR GeneID; 8312453; -.
DR KEGG; pcs:Pc22g02040; -.
DR VEuPathDB; FungiDB:PCH_Pc22g02040; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR OMA; TQECKCV; -.
DR OrthoDB; 995692at2759; -.
DR BioCyc; PCHR:PC22G02040-MON; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..458
FT /note="Nuclear distribution protein nudF 1"
FT /id="PRO_0000405088"
FT DOMAIN 9..41
FT /note="LisH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
FT REPEAT 113..154
FT /note="WD 1"
FT REPEAT 156..196
FT /note="WD 2"
FT REPEAT 200..247
FT /note="WD 3"
FT REPEAT 250..289
FT /note="WD 4"
FT REPEAT 292..353
FT /note="WD 5"
FT REPEAT 354..393
FT /note="WD 6"
FT REPEAT 397..439
FT /note="WD 7"
FT REPEAT 441..458
FT /note="WD 8"
FT COILED 60..87
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 458 AA; 50144 MW; 64F8F817B6BC3CE0 CRC64;
MSQLLTSRQA EELHKGIIAY LTSVNLHHSS AALREELGDS IRVDDTTLKK YEGLLEKKWT
SVVRLQKKIM DLEARCASLQ SELDTATPTS LNRKNQDPVS WLPRAPARHD LESHRSPVSC
LAFHPIFSSL ASGSDDTTIK IWDWELGELE RTIKGHTRAV LDVDYGGPRG GTLLASCSSD
LTIKLWDPAD EYKNIRTLPG HDHSVSAVRF IPSGAAGSPM SGNLLVSASR DLTLRIWDVT
TGYCVKSMQG HGDWIRDVTP SPDGRFLFSG GDDRVARLWD ISSGDTKSTF LGHEHYIECV
AFAPPTSYPH FAALAGLKKP PPASSSAEFV ATGSRDKTIR LWDTRGNCIK TLVGHDNWVR
SLVFHPGGKY LLSVSDDKTL RCWDLTQECK CVRTIVAHGH FISSLRWAPP LVKDAGANEG
ANGTEAASNG AKEDATKMSI RCVLATGSVD LKVRVFAA
