LIS11_UNCRE
ID LIS11_UNCRE Reviewed; 446 AA.
AC C4JZS6;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Nuclear distribution protein PAC1-1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=Lissencephaly-1 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE Short=LIS-1 1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=nudF homolog 1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=PAC1-1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Synonyms=LIS1-1 {ECO:0000255|HAMAP-Rule:MF_03141}; ORFNames=UREG_07677;
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. May enhance dynein-mediated
CC microtubule sliding by targeting dynein to the microtubule plus end.
CC Required for nuclear migration during vegetative growth as well as
CC development. Required for retrograde early endosome (EE) transport from
CC the hyphal tip. Required for localization of dynein to the mitotic
CC spindle poles. Recruits additional proteins to the dynein complex at
CC SPBs. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBUNIT: Self-associates. Interacts with NDL1 and dynein.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus ends of
CC microtubules at the hyphal tip and the mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; CH476619; EEP82812.1; -; Genomic_DNA.
DR RefSeq; XP_002582904.1; XM_002582858.1.
DR AlphaFoldDB; C4JZS6; -.
DR SMR; C4JZS6; -.
DR STRING; 33188.XP_002582904.1; -.
DR EnsemblFungi; EEP82812; EEP82812; UREG_07677.
DR GeneID; 8439693; -.
DR KEGG; ure:UREG_07677; -.
DR VEuPathDB; FungiDB:UREG_07677; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR InParanoid; C4JZS6; -.
DR OrthoDB; 995692at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..446
FT /note="Nuclear distribution protein PAC1-1"
FT /id="PRO_0000405111"
FT DOMAIN 9..41
FT /note="LisH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
FT REPEAT 112..153
FT /note="WD 1"
FT REPEAT 155..195
FT /note="WD 2"
FT REPEAT 199..239
FT /note="WD 3"
FT REPEAT 242..281
FT /note="WD 4"
FT REPEAT 284..344
FT /note="WD 5"
FT REPEAT 346..385
FT /note="WD 6"
FT REPEAT 390..430
FT /note="WD 7"
FT REPEAT 432..446
FT /note="WD 8"
FT COILED 60..86
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 446 AA; 48945 MW; 2ECE1F22D91AC320 CRC64;
MSQILTGRQA EELHKSLIAY LSSINASQSV TTLREELQIG DNFTDAACKK YEGFLEKKWI
SVVRLQKRIL DLESKIASLQ AELDSAPTIT SRANRDPKSW LPGTSPTHTL GSHRGAITCV
AFHPVFSSLA SGSEDYSIKI WDWELGELER TLKGHTRTVT GLDFGGQKGR TLLASCSNDL
TIKLWDPSND YANIRTLFGH DHSVSSVRFL IPGGNILISA SRDTTLRMWD TSTGFCVKTI
HTQGDWVRDV FPSFDGKWLV SGGRDQAATI WEVSSGEARA SLLGHENYIE CCTFAPPSSY
GYLATLAGLK KPPSTNSSAE FVATGARDKT VKLWDSRGSL IKTLIGHNNW VRGLVFHPGG
KYLFSVGDDK TIRCWDLSQE GKLVKTLEGA HEHFVSCIQW APDPANLVQS SVAERPEGNK
GTEHGTTGFR CVIATGSADS CVRVFM
