LIS12_UNCRE
ID LIS12_UNCRE Reviewed; 459 AA.
AC C4JPW9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Nuclear distribution protein PAC1-2 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=Lissencephaly-1 homolog 2 {ECO:0000255|HAMAP-Rule:MF_03141};
DE Short=LIS-1 2 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=nudF homolog 2 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=PAC1-2 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Synonyms=LIS1-2 {ECO:0000255|HAMAP-Rule:MF_03141}; ORFNames=UREG_04612;
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. May enhance dynein-mediated
CC microtubule sliding by targeting dynein to the microtubule plus end.
CC Required for nuclear migration during vegetative growth as well as
CC development. Required for retrograde early endosome (EE) transport from
CC the hyphal tip. Required for localization of dynein to the mitotic
CC spindle poles. Recruits additional proteins to the dynein complex at
CC SPBs. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBUNIT: Self-associates. Interacts with NDL1 and dynein.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus ends of
CC microtubules at the hyphal tip and the mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; CH476616; EEP79766.1; -; Genomic_DNA.
DR RefSeq; XP_002545095.1; XM_002545049.1.
DR AlphaFoldDB; C4JPW9; -.
DR SMR; C4JPW9; -.
DR STRING; 336963.C4JPW9; -.
DR EnsemblFungi; EEP79766; EEP79766; UREG_04612.
DR GeneID; 8440810; -.
DR KEGG; ure:UREG_04612; -.
DR VEuPathDB; FungiDB:UREG_04612; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR InParanoid; C4JPW9; -.
DR OrthoDB; 995692at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..459
FT /note="Nuclear distribution protein PAC1-2"
FT /id="PRO_0000405112"
FT REPEAT 108..149
FT /note="WD 1"
FT REPEAT 151..191
FT /note="WD 2"
FT REPEAT 195..244
FT /note="WD 3"
FT REPEAT 246..284
FT /note="WD 4"
FT REPEAT 306..348
FT /note="WD 5"
FT REPEAT 350..389
FT /note="WD 6"
FT REPEAT 394..438
FT /note="WD 7"
FT REPEAT 440..459
FT /note="WD 8"
FT COILED 56..83
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 459 AA; 50293 MW; 57519E8ABB3FBD69 CRC64;
MKIGFWTWKS IKLSIAIPLM CSHVSSALRA ELGLDEEAFG TAAAKKYETL LEKKWTSIVR
LQKKIMDLES RNAALQTELA NLTPTALSKR HQDPASWLPR SVRHSLESHR DTINSIAFHP
IYSSLASCSD DCTIKIWDWE LGELERTVKG HTRAVLDVDY GGPRSSILLA SCSSDLSIKL
WDPADEYKNI RTLLGHDHSV GAVRFIPSGA SGTLSSGNLL VSASRDGTLR IWDVVTGYCV
KTLRGHTAWV RDVCPSFDGR FLLSAGDDMT TRLWNISGSN SDHKLTMLGH EHVIECCALA
PFASYQYLAA LTGLKAPPAS SAAEFMATGS RDKTIKLWDA HGRCLGTLIG HDNWVRALAF
HPGGKYLLSV SDDKTLRCWD LSQGGKCVKT LKDAHERFIT CLRWAPGIFK NVPGVSTRDA
NGESNGVLNT GLKGDTPDVQ VRCVIATGGV DKKLQVFAD
