LIS1_DEBHA
ID LIS1_DEBHA Reviewed; 529 AA.
AC Q6BUA6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Nuclear distribution protein PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
DE Short=LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=nudF homolog {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Synonyms=LIS1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN OrderedLocusNames=DEHA2C12386g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. Plays a central role in positioning
CC the mitotic spindle at the bud neck during cell division. Targets
CC cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-
CC mediated microtubule sliding along the bud cortex and consequently the
CC movement of the mitotic spindle to the bud neck. {ECO:0000255|HAMAP-
CC Rule:MF_03141}.
CC -!- SUBUNIT: Self-associates. Interacts with NDL1 and dynein.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton,
CC spindle pole {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the
CC plus ends of microtubules and the mitotic spindle poles.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; CR382135; CAG86289.2; -; Genomic_DNA.
DR RefSeq; XP_458213.2; XM_458213.1.
DR AlphaFoldDB; Q6BUA6; -.
DR SMR; Q6BUA6; -.
DR STRING; 4959.XP_458213.2; -.
DR EnsemblFungi; CAG86289; CAG86289; DEHA2C12386g.
DR GeneID; 2900137; -.
DR KEGG; dha:DEHA2C12386g; -.
DR VEuPathDB; FungiDB:DEHA2C12386g; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR InParanoid; Q6BUA6; -.
DR OMA; LTHWPSG; -.
DR OrthoDB; 995692at2759; -.
DR Proteomes; UP000000599; Chromosome C.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 2.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..529
FT /note="Nuclear distribution protein PAC1"
FT /id="PRO_0000240425"
FT REPEAT 120..159
FT /note="WD 1"
FT REPEAT 165..218
FT /note="WD 2"
FT REPEAT 221..261
FT /note="WD 3"
FT REPEAT 264..318
FT /note="WD 4"
FT REPEAT 321..395
FT /note="WD 5"
FT REPEAT 416..455
FT /note="WD 6"
FT REPEAT 496..529
FT /note="WD 7"
FT COILED 68..89
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 529 AA; 58896 MW; F96740E1DB20991A CRC64;
MLQPQILTAR QQQELNKAII QYIKPIAEEA NDGDLIQKLS ESLDVPLGSI DDSVIPNYLE
KKWSTVLRLQ HKIIDLEGEV SNLRTVIDSQ QIVPSASASV IGKDKINWLP SSSIKAFKTQ
SHQLVQSVSI HPALPIILGG CSDGSLIIWN LVNDESLIPE KIIKAHIRGV NTIAWSKKPV
DLSGKGSEAK GIAHVMATCS SDLSIKIWDG ATFKHIRTLT GHEHTISSIV FSASKPNILY
SVSRDKSVKV WDLVNGYCIK TFIGHSDWVR DIDVISVNSN LLQEQSDINP ELGDFLVTCS
NDQSIRLSHA ESGTGLSLSI GHTHVIECVK FLPFHSNYII DKYIKENESL FPNISPEVLD
DPNYTNLLGY KYCISGGRDN SVKLWLLPPP VFRPHRHPLP SQLNNSQGWL IADLVGHQSW
VKSLHIHPNG RFVFSGSDDK TIKIWDLSSL NVNGRVKCVK NLIGHEGFVN DIEFASFEIT
NNIHASKTAD DGKTKTEEDR RNELMKSIES KIRCLFISGG VDNCIRLWS
