LIS1_DROAN
ID LIS1_DROAN Reviewed; 411 AA.
AC B3MEY6;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=Lis-1 {ECO:0000255|HAMAP-Rule:MF_03141}; ORFNames=GF11864;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. May enhance dynein-mediated
CC microtubule sliding by targeting dynein to the microtubule plus end.
CC Required for several dynein- and microtubule-dependent processes.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the
CC plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-
CC Rule:MF_03141}.
CC -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH902619; EDV36607.1; -; Genomic_DNA.
DR RefSeq; XP_001959785.1; XM_001959749.2.
DR AlphaFoldDB; B3MEY6; -.
DR SMR; B3MEY6; -.
DR STRING; 7217.FBpp0115056; -.
DR EnsemblMetazoa; FBtr0116564; FBpp0115056; FBgn0088904.
DR GeneID; 6494726; -.
DR KEGG; dan:6494726; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR InParanoid; B3MEY6; -.
DR OMA; TQECKCV; -.
DR OrthoDB; 995692at2759; -.
DR PhylomeDB; B3MEY6; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR GO; GO:0005869; C:dynactin complex; IEA:EnsemblMetazoa.
DR GO; GO:0030286; C:dynein complex; IEA:EnsemblMetazoa.
DR GO; GO:0030426; C:growth cone; IEA:EnsemblMetazoa.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0043025; C:neuronal cell body; IEA:EnsemblMetazoa.
DR GO; GO:0031616; C:spindle pole centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0051299; P:centrosome separation; IEA:EnsemblMetazoa.
DR GO; GO:0030381; P:chorion-containing eggshell pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0061883; P:clathrin-dependent endocytosis involved in vitellogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007303; P:cytoplasmic transport, nurse cell to oocyte; IEA:EnsemblMetazoa.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0048142; P:germarium-derived cystoblast division; IEA:EnsemblMetazoa.
DR GO; GO:0007294; P:germarium-derived oocyte fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblMetazoa.
DR GO; GO:0006886; P:intracellular protein transport; IEA:EnsemblMetazoa.
DR GO; GO:0051383; P:kinetochore organization; IEA:EnsemblMetazoa.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0030473; P:nuclear migration along microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0007312; P:oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0030723; P:ovarian fusome organization; IEA:EnsemblMetazoa.
DR GO; GO:0072499; P:photoreceptor cell axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:EnsemblMetazoa.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008090; P:retrograde axonal transport; IEA:EnsemblMetazoa.
DR GO; GO:0042052; P:rhabdomere development; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0051225; P:spindle assembly; IEA:EnsemblMetazoa.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:EnsemblMetazoa.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 7.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 6.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..411
FT /note="Lissencephaly-1 homolog"
FT /id="PRO_0000405040"
FT DOMAIN 9..41
FT /note="LisH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
FT REPEAT 106..147
FT /note="WD 1"
FT REPEAT 148..187
FT /note="WD 2"
FT REPEAT 191..230
FT /note="WD 3"
FT REPEAT 233..272
FT /note="WD 4"
FT REPEAT 275..334
FT /note="WD 5"
FT REPEAT 337..376
FT /note="WD 6"
FT REPEAT 379..411
FT /note="WD 7"
FT COILED 56..83
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 411 AA; 46446 MW; D8CB0F7FAC97918A CRC64;
MKMVLSQRQR EELNQAIADY LGSNGYADSL EAFRKEADLS TEAEKKFGGL LEKKWTSVIR
LQKKVMELEA KLTEAEKEVI EGAPTKNKRT PGEWIPRPPE KYSMSGHRAS ITRVIFHPIF
GLVVSASEDA TIKIWDFETG EYERSLKGHT DSVQDVAFDA QGKLLASCSA DLSIKLWDFQ
QTYECVKTMH GHDHNVSSVA FVPAGDYVLS ASRDRTVKMW EVATGYCVKT YTGHREWVRM
VRVHIEGSIF ATCSNDHTIR VWLTNSRDCK VELRDHEHTV ECIAWAPEAA ASAINEAAGA
DNKKGHHQGP FLASGSRDKT IRIWDVSVGL CLFTLNGHDN WVRGLAFHPA GKYLVSASDD
KTIRVWDLRN KRCMKTLYAH QHFCTSIDFH KAHPYVISGS VDQTVKVWEC R
