LIS1_DROER
ID LIS1_DROER Reviewed; 411 AA.
AC B3NPW0;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=Lis-1 {ECO:0000255|HAMAP-Rule:MF_03141}; ORFNames=GG20577;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. May enhance dynein-mediated
CC microtubule sliding by targeting dynein to the microtubule plus end.
CC Required for several dynein- and microtubule-dependent processes.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the
CC plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-
CC Rule:MF_03141}.
CC -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; CH954179; EDV55807.1; -; Genomic_DNA.
DR RefSeq; XP_001975407.1; XM_001975371.2.
DR AlphaFoldDB; B3NPW0; -.
DR SMR; B3NPW0; -.
DR STRING; 7220.FBpp0139123; -.
DR EnsemblMetazoa; FBtr0140631; FBpp0139123; FBgn0112767.
DR GeneID; 6548525; -.
DR KEGG; der:6548525; -.
DR eggNOG; KOG0295; Eukaryota.
DR HOGENOM; CLU_000288_57_15_1; -.
DR OMA; TQECKCV; -.
DR OrthoDB; 995692at2759; -.
DR PhylomeDB; B3NPW0; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
DR GO; GO:0005869; C:dynactin complex; IEA:EnsemblMetazoa.
DR GO; GO:0030286; C:dynein complex; IEA:EnsemblMetazoa.
DR GO; GO:0030426; C:growth cone; IEA:EnsemblMetazoa.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0043025; C:neuronal cell body; IEA:EnsemblMetazoa.
DR GO; GO:0031616; C:spindle pole centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0051299; P:centrosome separation; IEA:EnsemblMetazoa.
DR GO; GO:0030381; P:chorion-containing eggshell pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0061883; P:clathrin-dependent endocytosis involved in vitellogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007303; P:cytoplasmic transport, nurse cell to oocyte; IEA:EnsemblMetazoa.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0048142; P:germarium-derived cystoblast division; IEA:EnsemblMetazoa.
DR GO; GO:0007294; P:germarium-derived oocyte fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0008298; P:intracellular mRNA localization; IEA:EnsemblMetazoa.
DR GO; GO:0006886; P:intracellular protein transport; IEA:EnsemblMetazoa.
DR GO; GO:0051383; P:kinetochore organization; IEA:EnsemblMetazoa.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0030473; P:nuclear migration along microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0007312; P:oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0030723; P:ovarian fusome organization; IEA:EnsemblMetazoa.
DR GO; GO:0072499; P:photoreceptor cell axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:EnsemblMetazoa.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008090; P:retrograde axonal transport; IEA:EnsemblMetazoa.
DR GO; GO:0042052; P:rhabdomere development; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0051225; P:spindle assembly; IEA:EnsemblMetazoa.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:EnsemblMetazoa.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 7.
DR PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 6.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Repeat; Transport; WD repeat.
FT CHAIN 1..411
FT /note="Lissencephaly-1 homolog"
FT /id="PRO_0000405041"
FT DOMAIN 9..41
FT /note="LisH"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
FT REPEAT 106..147
FT /note="WD 1"
FT REPEAT 148..187
FT /note="WD 2"
FT REPEAT 191..230
FT /note="WD 3"
FT REPEAT 233..272
FT /note="WD 4"
FT REPEAT 275..334
FT /note="WD 5"
FT REPEAT 337..376
FT /note="WD 6"
FT REPEAT 379..411
FT /note="WD 7"
FT COILED 56..83
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 411 AA; 46446 MW; 336A27A5DC7BFB62 CRC64;
MKMVLSQRQR EELNQAIADY LGSNGYADSL ETFRKEADLS TEVEKKFGGL LEKKWTSVIR
LQKKVMELEA KLTEAEKEVI EGAPTKNKRT PGEWIPRPPE KFSLTGHRAS ITRVIFHPIF
GLMVSASEDA TIRIWDFETG EYERSLKGHT DSVQDVAFDA QGKLLASCSA DLSIKLWDFQ
QSYECIKTMH GHDHNVSSVA FVPAGDYVLS ASRDRTIKMW EVATGYCVKT YTGHREWVRM
VRVHIEGSIF ATCSNDQTIR VWLTNSKDCK VELRDHEHTV ECIAWAPEAA ASAINEAAGA
DNKKGHHQGP FLASGSRDKT IRIWDVSVGL CLLTLSGHDN WVRGLAFHPG GKYLVSASDD
KTIRVWDLRN KRCMKTLYAH QHFCTSIDFH KAHPYVISGS VDQTVKVWEC R
