ID   LIS1_GLOMM              Reviewed;         411 AA.
AC   D3TLL6;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=20353571; DOI=10.1186/1471-2164-11-213;
RA   Alves-Silva J., Ribeiro J.M., Van Den Abbeele J., Attardo G., Hao Z.,
RA   Haines L.R., Soares M.B., Berriman M., Aksoy S., Lehane M.J.;
RT   "An insight into the sialome of Glossina morsitans morsitans.";
RL   BMC Genomics 11:213-213(2010).
CC   -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC       microtubule motor protein dynein. May enhance dynein-mediated
CC       microtubule sliding by targeting dynein to the microtubule plus end.
CC       Required for several dynein- and microtubule-dependent processes.
CC       {ECO:0000255|HAMAP-Rule:MF_03141}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC       Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC       centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the
CC       plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03141}.
CC   -!- DOMAIN: Dimerization mediated by the LisH domain may be required to
CC       activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
CC   -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC       {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR   EMBL; EZ422318; ADD18594.1; -; mRNA.
DR   AlphaFoldDB; D3TLL6; -.
DR   SMR; D3TLL6; -.
DR   STRING; 37546.D3TLL6; -.
DR   PRIDE; D3TLL6; -.
DR   VEuPathDB; VectorBase:GMOY000875; -.
DR   PhylomeDB; D3TLL6; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR   GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03141; lis1; 1.
DR   InterPro; IPR017252; Dynein_regulator_LIS1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037190; LIS1_N.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08513; LisH; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PIRSF; PIRSF037647; Dynein_regulator_Lis1; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF109925; SSF109925; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 6.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Repeat; Transport; WD repeat.
FT   CHAIN           1..411
FT                   /note="Lissencephaly-1 homolog"
FT                   /id="PRO_0000405051"
FT   DOMAIN          9..41
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
FT   REPEAT          106..147
FT                   /note="WD 1"
FT   REPEAT          149..187
FT                   /note="WD 2"
FT   REPEAT          191..230
FT                   /note="WD 3"
FT   REPEAT          233..272
FT                   /note="WD 4"
FT   REPEAT          275..334
FT                   /note="WD 5"
FT   REPEAT          337..376
FT                   /note="WD 6"
FT   REPEAT          379..411
FT                   /note="WD 7"
FT   COILED          56..83
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ   SEQUENCE   411 AA;  46497 MW;  D3EC3E46FB8B0019 CRC64;
     MKMVLSQRQR EELNQAIADY LGSNGYSSAL EAFRKEADIS GEAERKIVGL LEKKWTSVIR
     LQKKVMELEA KLSEAEKEVI EGAPSRAKRS PGEWIPRPPE KFSLSGHRAS ITRVIFHPTY
     SLMLSASEDA VIKIWDFETG EYERSLKGHT SSVQDIAFDS QGKLLASCSA DLSIKLWDFQ
     QSYDCVKTML GHDHNVSSVA FVPAGDYVLS ASRDQTIKMW EVATGYCVKT YSGHREWIRM
     VRVHMDGNIF ASCSIDHSIR IWSINSRDCK AELRAHDHTV ECIAWAPDIS TTHINEAAGS
     DNKKGHHQGP FLASGSRDKT IRVWDVGVGL CLFVLTGHDN WVRELTFHPG GKYLVSASDD
     KTIRVWDLRN KRFMKTLYAH QHFCTSVDFH KKLPYVISGS VDNTVKVWEC R