LIS1_ZYGRC
ID LIS1_ZYGRC Reviewed; 444 AA.
AC C5DY07;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Nuclear distribution protein PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=Lissencephaly-1 homolog {ECO:0000255|HAMAP-Rule:MF_03141};
DE Short=LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141};
DE AltName: Full=nudF homolog {ECO:0000255|HAMAP-Rule:MF_03141};
GN Name=PAC1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN Synonyms=LIS1 {ECO:0000255|HAMAP-Rule:MF_03141};
GN OrderedLocusNames=ZYRO0F09284g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Positively regulates the activity of the minus-end directed
CC microtubule motor protein dynein. Plays a central role in positioning
CC the mitotic spindle at the bud neck during cell division. Targets
CC cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-
CC mediated microtubule sliding along the bud cortex and consequently the
CC movement of the mitotic spindle to the bud neck. {ECO:0000255|HAMAP-
CC Rule:MF_03141}.
CC -!- SUBUNIT: Self-associates. Interacts with NDL1 and dynein.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-
CC Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus ends of
CC microtubules and the mitotic spindle poles. {ECO:0000255|HAMAP-
CC Rule:MF_03141}.
CC -!- SIMILARITY: Belongs to the WD repeat LIS1/nudF family.
CC {ECO:0000255|HAMAP-Rule:MF_03141}.
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DR EMBL; CU928178; CAR28668.1; -; Genomic_DNA.
DR RefSeq; XP_002497601.1; XM_002497556.1.
DR AlphaFoldDB; C5DY07; -.
DR SMR; C5DY07; -.
DR STRING; 559307.C5DY07; -.
DR EnsemblFungi; CAR28668; CAR28668; ZYRO0F09284g.
DR GeneID; 8205365; -.
DR KEGG; zro:ZYRO0F09284g; -.
DR HOGENOM; CLU_000288_57_15_1; -.
DR InParanoid; C5DY07; -.
DR Proteomes; UP000008536; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:UniProtKB-UniRule.
DR GO; GO:0051012; P:microtubule sliding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03141; lis1; 1.
DR InterPro; IPR017252; Dynein_regulator_LIS1.
DR InterPro; IPR037190; LIS1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF109925; SSF109925; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..444
FT /note="Nuclear distribution protein PAC1"
FT /id="PRO_0000405113"
FT REPEAT 113..152
FT /note="WD 1"
FT REPEAT 156..199
FT /note="WD 2"
FT REPEAT 204..251
FT /note="WD 3"
FT REPEAT 254..293
FT /note="WD 4"
FT REPEAT 307..347
FT /note="WD 5"
FT REPEAT 367..406
FT /note="WD 6"
FT REPEAT 408..444
FT /note="WD 7"
FT COILED 59..87
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03141"
SQ SEQUENCE 444 AA; 49929 MW; 0CA8FAF71F172AC4 CRC64;
MDLPLSDEQI RELDESTLDY LLWRNKGIDI TQLANSLQVD APTLQEDTNR LPLLARKWTA
IARLQRRIMS LEQNIRDLRE ASIEMNAPAF SPESSESARI AWIAPAQPRA SITLESPVTG
VRLHPELAVV FVSTEQGRLH CFDLMDITLP LASIQAHTRA ITSVDVFCWQ QTTYVVTGSK
DMQVRVFTWS AGQGLKLLRS FAGHEHVVSG VRIWVGPRTT NIGGGSLLLA SCSRDTSVKI
WDVNSGWCLK SFQPHSDWVR CLDVYGEFLI TGCQDSTLRL THWPSGNGLS VGLGHDFPVE
SVRFIGSLQD AVTTEGRTNN WLGHCVSTSR DRTSKIWLLP QPRRLPQRPP VPHSTDAQFL
CKWTLRGHDS WIKAVGSRGD HVFTASDDKS VICWNWTNGQ CLKKWNRIHQ GFVTCIDLDD
SNHPLKRKIM VTGGIDCKCH IFMQ
