LIT1_MOUSE
ID LIT1_MOUSE Reviewed; 165 AA.
AC P43137;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Lithostathine-1;
DE AltName: Full=Islet of Langerhans regenerating protein 1;
DE Short=REG 1;
DE AltName: Full=Pancreatic stone protein 1;
DE Short=PSP;
DE AltName: Full=Pancreatic thread protein 1;
DE Short=PTP;
DE AltName: Full=Regenerating protein 1;
DE Flags: Precursor;
GN Name=Reg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=8340418; DOI=10.1016/s0021-9258(18)82347-x;
RA Unno M., Yonekura H., Nakagawara K., Watanabe T., Miyashita H.,
RA Moriizumi S., Okamoto H., Itoh T., Teraoka H.;
RT "Structure, chromosomal localization, and expression of mouse reg genes,
RT reg I and reg II. A novel type of reg gene, reg II, exists in the mouse
RT genome.";
RL J. Biol. Chem. 268:15974-15982(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Might act as an inhibitor of spontaneous calcium carbonate
CC precipitation.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed only in regenerating islets and normal
CC exocrine pancreas, but not in normal pancreatic islets. Expressed
CC strongly in pancreas, moderately in gall bladder, and weakly in liver.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=Litho/Reg 1alpha;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_182";
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DR EMBL; D14010; BAA03111.1; -; Genomic_DNA.
DR EMBL; BC028761; AAH28761.1; -; mRNA.
DR CCDS; CCDS20257.1; -.
DR PIR; A47148; A47148.
DR RefSeq; NP_033068.1; NM_009042.1.
DR AlphaFoldDB; P43137; -.
DR SMR; P43137; -.
DR BioGRID; 202848; 5.
DR STRING; 10090.ENSMUSP00000078847; -.
DR GlyGen; P43137; 1 site.
DR iPTMnet; P43137; -.
DR PhosphoSitePlus; P43137; -.
DR PaxDb; P43137; -.
DR PeptideAtlas; P43137; -.
DR PRIDE; P43137; -.
DR ProteomicsDB; 292264; -.
DR DNASU; 19692; -.
DR Ensembl; ENSMUST00000079926; ENSMUSP00000078847; ENSMUSG00000059654.
DR Ensembl; ENSMUST00000204601; ENSMUSP00000144840; ENSMUSG00000059654.
DR Ensembl; ENSMUST00000204687; ENSMUSP00000145161; ENSMUSG00000059654.
DR GeneID; 19692; -.
DR KEGG; mmu:19692; -.
DR UCSC; uc009cka.1; mouse.
DR CTD; 19692; -.
DR MGI; MGI:97895; Reg1.
DR VEuPathDB; HostDB:ENSMUSG00000059654; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000162393; -.
DR HOGENOM; CLU_049894_18_0_1; -.
DR InParanoid; P43137; -.
DR OMA; NGFGYHN; -.
DR OrthoDB; 1509611at2759; -.
DR PhylomeDB; P43137; -.
DR BioGRID-ORCS; 19692; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Reg1; mouse.
DR PRO; PR:P43137; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P43137; protein.
DR Bgee; ENSMUSG00000059654; Expressed in duodenum and 43 other tissues.
DR ExpressionAtlas; P43137; baseline and differential.
DR Genevisible; P43137; MM.
DR GO; GO:0045178; C:basal part of cell; ISO:MGI.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0032590; C:dendrite membrane; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0030426; C:growth cone; ISO:MGI.
DR GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0042588; C:zymogen granule; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0070492; F:oligosaccharide binding; IBA:GO_Central.
DR GO; GO:0042834; F:peptidoglycan binding; IBA:GO_Central.
DR GO; GO:0019902; F:phosphatase binding; ISO:MGI.
DR GO; GO:0019903; F:protein phosphatase binding; ISO:MGI.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0055074; P:calcium ion homeostasis; ISO:MGI.
DR GO; GO:0044278; P:cell wall disruption in another organism; IBA:GO_Central.
DR GO; GO:1990869; P:cellular response to chemokine; IEA:Ensembl.
DR GO; GO:1990878; P:cellular response to gastrin; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0097421; P:liver regeneration; IEA:Ensembl.
DR GO; GO:0007494; P:midgut development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:1990798; P:pancreas regeneration; IMP:MGI.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IMP:MGI.
DR GO; GO:1904699; P:positive regulation of acinar cell proliferation; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903861; P:positive regulation of dendrite extension; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:MGI.
DR GO; GO:1904692; P:positive regulation of type B pancreatic cell proliferation; ISO:MGI.
DR GO; GO:1903492; P:response to acetylsalicylate; IEA:Ensembl.
DR GO; GO:1990864; P:response to growth hormone-releasing hormone; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0031667; P:response to nutrient levels; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR GO; GO:1990785; P:response to water-immersion restraint stress; IEA:Ensembl.
DR GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:MGI.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..165
FT /note="Lithostathine-1"
FT /id="PRO_0000017426"
FT DOMAIN 33..163
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P05451"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 35..46
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 63..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 136..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 165 AA; 18519 MW; 2950174AF5D666BA CRC64;
MARNAYFILL SCLIVLSPSQ GQEAEEDLPS ARISCPEGSN AYSSYCYYFT EDRLTWADAD
LFCQNMNSGY LVSVLSQAEG NFVASLIKES GTTDANVWTG LHDPKRNRRW HWSSGSLFLY
KSWATGSPNS SNRGYCVSLT SNTGYKKWKD DNCDAQYSFV CKFKG
