ID   LITAD_HUMAN             Reviewed;          72 AA.
AC   A0A1B0GVX0;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=LITAF domain-containing protein {ECO:0000305};
DE   AltName: Full=LITAF-like protein {ECO:0000305};
GN   Name=LITAFD {ECO:0000312|HGNC:HGNC:53927};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU01181};
CC       Peripheral membrane protein {ECO:0000255|PROSITE-ProRule:PRU01181}.
CC   -!- DOMAIN: The LITAF domain is stabilized by a bound zinc ion. The LITAF
CC       domain contains an amphipathic helix that mediates interaction with
CC       lipid membranes. {ECO:0000250|UniProtKB:Q99732}.
CC   -!- SIMILARITY: Belongs to the CDIP1/LITAF family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC022167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0GVX0; -.
DR   BioMuta; ENSG00000283516; -.
DR   Ensembl; ENST00000636296.1; ENSP00000490685.1; ENSG00000283516.1.
DR   Ensembl; ENST00000637237.1; ENSP00000490446.1; ENSG00000283516.1.
DR   MANE-Select; ENST00000636296.2; ENSP00000490685.1; NM_001395433.1; NP_001382362.1.
DR   GeneCards; LITAFD; -.
DR   HGNC; HGNC:53927; LITAFD.
DR   HPA; ENSG00000283516; Tissue enriched (testis).
DR   neXtProt; NX_A0A1B0GVX0; -.
DR   VEuPathDB; HostDB:ENSG00000283516; -.
DR   GeneTree; ENSGT00940000163474; -.
DR   OMA; QIACPQC; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A0A1B0GVX0; protein.
DR   Bgee; ENSG00000283516; Expressed in left testis and 37 other tissues.
DR   ExpressionAtlas; A0A1B0GVX0; baseline and differential.
DR   GO; GO:0098560; C:cytoplasmic side of late endosome membrane; IBA:GO_Central.
DR   GO; GO:0098574; C:cytoplasmic side of lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   InterPro; IPR006629; LITAF.
DR   InterPro; IPR037519; LITAF_fam.
DR   PANTHER; PTHR23292; PTHR23292; 1.
DR   Pfam; PF10601; zf-LITAF-like; 1.
DR   SMART; SM00714; LITAF; 1.
DR   PROSITE; PS51837; LITAF; 1.
PE   5: Uncertain;
KW   Membrane; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..72
FT                   /note="LITAF domain-containing protein"
FT                   /id="PRO_0000447323"
FT   DOMAIN          1..71
FT                   /note="LITAF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01181"
FT   REGION          22..45
FT                   /note="Membrane-binding amphipathic helix"
FT                   /evidence="ECO:0000250|UniProtKB:Q99732"
FT   BINDING         7
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01181"
FT   BINDING         10
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01181"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01181"
FT   BINDING         62
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01181"
SQ   SEQUENCE   72 AA;  8245 MW;  B0098659E46AC419 CRC64;
     MPVQAVCPYC GNRIITVTTF VPGALTWLLC TTLFLFGYVL GCCFLAFCIR SLMDVKHSCP
     VCQRELFYYH RL