LITD1_MOUSE
ID LITD1_MOUSE Reviewed; 782 AA.
AC Q587J6; Q3UKY3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=LINE-1 type transposase domain-containing protein 1;
DE AltName: Full=ES cell-associated protein 11;
GN Name=L1td1; Synonyms=Ecat11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yamanaka S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-385.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SIMILARITY: Belongs to the transposase 22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE26668.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB211064; BAD95491.1; -; mRNA.
DR EMBL; AK145814; BAE26668.1; ALT_INIT; mRNA.
DR CCDS; CCDS51235.1; -.
DR RefSeq; NP_001074671.1; NM_001081202.1.
DR AlphaFoldDB; Q587J6; -.
DR SMR; Q587J6; -.
DR BioGRID; 238004; 9.
DR DIP; DIP-59746N; -.
DR IntAct; Q587J6; 1.
DR STRING; 10090.ENSMUSP00000127504; -.
DR iPTMnet; Q587J6; -.
DR PhosphoSitePlus; Q587J6; -.
DR EPD; Q587J6; -.
DR PaxDb; Q587J6; -.
DR PRIDE; Q587J6; -.
DR ProteomicsDB; 286210; -.
DR Antibodypedia; 33329; 83 antibodies from 23 providers.
DR DNASU; 381591; -.
DR Ensembl; ENSMUST00000154279; ENSMUSP00000127504; ENSMUSG00000087166.
DR GeneID; 381591; -.
DR KEGG; mmu:381591; -.
DR UCSC; uc008tuj.1; mouse.
DR CTD; 54596; -.
DR MGI; MGI:3578435; L1td1.
DR VEuPathDB; HostDB:ENSMUSG00000087166; -.
DR eggNOG; ENOG502SRQ0; Eukaryota.
DR GeneTree; ENSGT01050000244818; -.
DR HOGENOM; CLU_336140_0_0_1; -.
DR InParanoid; Q587J6; -.
DR OrthoDB; 455018at2759; -.
DR PhylomeDB; Q587J6; -.
DR TreeFam; TF351152; -.
DR BioGRID-ORCS; 381591; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q587J6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q587J6; protein.
DR Bgee; ENSMUSG00000087166; Expressed in yolk sac and 49 other tissues.
DR ExpressionAtlas; Q587J6; baseline and differential.
DR Genevisible; Q587J6; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0032197; P:transposition, RNA-mediated; IBA:GO_Central.
DR Gene3D; 3.30.250.20; -; 2.
DR InterPro; IPR042566; L1_C.
DR InterPro; IPR035300; L1_dsRBD.
DR InterPro; IPR043636; L1_RRM_dom.
DR InterPro; IPR004244; Transposase_22.
DR PANTHER; PTHR11505; PTHR11505; 1.
DR Pfam; PF17490; Tnp_22_dsRBD; 2.
DR Pfam; PF02994; Transposase_22; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..782
FT /note="LINE-1 type transposase domain-containing protein 1"
FT /id="PRO_0000307218"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..395
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 407
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 478
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 490
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 559
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
FT MOD_RES 567
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5T7N2"
SQ SEQUENCE 782 AA; 88189 MW; 1A77199FD6CFC5A0 CRC64;
MSGVQSKAAR LQKERKEKLS ADRERKTATS LCLKHSEVPA SMMKQFNALM EMQEVMFAEM
RETYKNDIKE MLLKRTAPWV KHLEERIGQQ EGDAISERPK PGEKVEELSS GTDEDTENLT
VRSKKGKQDK AKPLNSSHVL KSSLERGGEA LRGEHGRCGE SSSLVDWKNA NEKPAREASC
QSEENRLKAP KESPPEGGAG ATLRLAADFS AATLDVGRQW SQVFRLLKEK ELEPELQCSV
KLAFKCDGEA NVFSDLHSLR QFTSRKPFLR ELLKDVFPQN EGGRRNELRE RLGKTLGDTK
HEARRIASDS LSFLFIKEVE VASPEVKTYK EETLDRKNKG TLKKQEGEEE EISETQGEET
SEGETSELGE EEGSESEEEE ESSESEEEEE SSESAEEIGF ISLVVDSESE EEVNRKTASQ
TKKKETFHGL KELAFSYLVW DSKKKKLVRC QEGGAAAAST QRIGMPCLTL YLTSPSESLG
AGSDGPKSHS CTKLSALSQV TPLLTNIEKG RYKVPQTEEP TAKEADLILE TEENFKRGVI
SVIRQMQREV DKIKNIYVSD VLNMKSSLDD LNSLACTIEA RVSEQEDAVE GLTKDTMQLA
REIVDKERLR EREDRFRSSN IRVIGIPEKE NRENGAVDII KEVIEENFAE LEDQSLEIVS
AHRVPNSVDE HRLTPRHILV KFGSASDKQR VLKASRAKQE ITYRGSKIRL TADLSPGTID
ARSQWCGIIK ILQDEGFQPR ILYPAKLAFD FKGKTKIFFD IEEFKKFISD IPYLKDLLNN
IH
