ID   LITL_PHYSA              Reviewed;          90 AA.
AC   P08948;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 3.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=[Leu8]-phyllolitorin;
DE   Flags: Precursor;
OS   Phyllomedusa sauvagei (Sauvage's leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8395;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7997236; DOI=10.1210/mend.8.8.7997236;
RA   Nagalla S.R., Barry B.J., Spindel E.R.;
RT   "Cloning of complementary DNAs encoding the amphibian bombesin-like
RT   peptides Phe8 and Leu8 phyllolitorin from Phyllomedusa sauvagei: potential
RT   role of U to C RNA editing in generating neuropeptide diversity.";
RL   Mol. Endocrinol. 8:943-951(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 49-57, PYROGLUTAMATE FORMATION AT GLN-49, AND AMIDATION
RP   AT MET-57.
RC   TISSUE=Skin secretion;
RX   PubMed=3868775; DOI=10.1016/0196-9781(85)90343-2;
RA   Erspamer V., Melchiorri P., Falconieri-Erspamer G., Montecucchi P.C.,
RA   de Castiglione R.;
RT   "Phyllomedusa skin: a huge factory and store-house of a variety of active
RT   peptides.";
RL   Peptides 6 Suppl. 3:7-12(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   EMBL; S77208; AAB32787.1; -; mRNA.
DR   PIR; A57058; A57058.
DR   AlphaFoldDB; P08948; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   PROPEP          31..48
FT                   /evidence="ECO:0000269|PubMed:3868775"
FT                   /id="PRO_0000003014"
FT   PEPTIDE         49..57
FT                   /note="[Leu8]-phyllolitorin"
FT                   /id="PRO_0000003015"
FT   PROPEP          61..90
FT                   /id="PRO_0000003016"
FT   MOD_RES         49
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3868775"
FT   MOD_RES         57
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:3868775"
SQ   SEQUENCE   90 AA;  10113 MW;  0BACBD4EE124CE3C CRC64;
     MSAVPFTRVL LISGFLAHLL LSTFVTLTVC KEVTEESDDL SKRNVLQRQL WAVGSLMGKK
     SLENTNRRSD EDMEISALFR GSPLKVKRSD