ID   LITO_RANAE              Reviewed;           9 AA.
AC   P08945;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   10-FEB-2021, entry version 73.
DE   RecName: Full=Litorin;
OS   Ranoidea aurea (Green and golden bell frog) (Litoria aurea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=8371;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT MET-9.
RC   TISSUE=Skin secretion;
RX   PubMed=1140241; DOI=10.1007/bf01932427;
RA   Anastasi A., Erspamer V., Endean R.;
RT   "Aminoacid composition and sequence of litorin, a bombesin-like nonapeptide
RT   from the skin of the Australian leptodactylid frog Litoria aurea.";
RL   Experientia 31:510-511(1975).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=908397; DOI=10.1007/bf01920138;
RA   Anastasi A., Montecucchi P.C., Angelucci F., Erspamer V., Endean R.;
RT   "Glu(OMe)3-litorin, the second bombesin-like peptide occurring in methanol
RT   extracts of the skin of the Australian frog Litoria aurea.";
RL   Experientia 33:1289-1289(1977).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
CC   -!- CAUTION: PubMed:908397 reported the formation of a glutamate methyl
CC       ester from Gln-2. This is most probably an artifact of isolation.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S07204; S07204.
DR   PIR; S07205; S07205.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..9
FT                   /note="Litorin"
FT                   /id="PRO_0000043493"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1140241"
FT   MOD_RES         9
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:1140241"
SQ   SEQUENCE   9 AA;  1103 MW;  D7CCC1E862CDC366 CRC64;
     QQWAVGHFM