ID   LIT_ECOLI               Reviewed;         297 AA.
AC   P11072; P77283;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Cell death peptidase {ECO:0000305};
DE   AltName: Full=Bacteriophage T4 late gene expression-blocking protein;
DE   AltName: Full=GpLit;
GN   Name=lit; OrderedLocusNames=b1139, JW1125;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / JM101 / ATCC 33876 / DSM 3948 / NCIMB 11926;
RX   PubMed=2452152; DOI=10.1128/jb.170.5.2056-2062.1988;
RA   Kao C., Snyder L.;
RT   "The lit gene product which blocks bacteriophage T4 late gene expression is
RT   a membrane protein encoded by a cryptic DNA element, e14.";
RL   J. Bacteriol. 170:2056-2062(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Interacts with a short DNA sequence about one-quarter of the
CC       way into the major capsid protein gene 23 of T4; general translation
CC       inhibition occurs when this late gene of the virus is expressed.
CC       {ECO:0000269|PubMed:2452152}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase U49 family. {ECO:0000305}.
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DR   EMBL; M19634; AAA24074.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC74223.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35968.1; -; Genomic_DNA.
DR   PIR; H64858; BVECLT.
DR   RefSeq; NP_415657.1; NC_000913.3.
DR   RefSeq; WP_001257372.1; NZ_CP047127.1.
DR   AlphaFoldDB; P11072; -.
DR   BioGRID; 4263099; 10.
DR   STRING; 511145.b1139; -.
DR   MEROPS; U49.001; -.
DR   PaxDb; P11072; -.
DR   PRIDE; P11072; -.
DR   EnsemblBacteria; AAC74223; AAC74223; b1139.
DR   EnsemblBacteria; BAA35968; BAA35968; BAA35968.
DR   GeneID; 948421; -.
DR   KEGG; ecj:JW1125; -.
DR   KEGG; eco:b1139; -.
DR   PATRIC; fig|511145.12.peg.1185; -.
DR   EchoBASE; EB0530; -.
DR   eggNOG; ENOG5033IJV; Bacteria.
DR   HOGENOM; CLU_979143_0_0_6; -.
DR   OMA; IWHEIAH; -.
DR   BioCyc; EcoCyc:EG10535-MON; -.
DR   PRO; PR:P11072; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IDA:EcoCyc.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0006448; P:regulation of translational elongation; IDA:EcoCyc.
DR   InterPro; IPR019504; Peptidase_U49_Lit_pept.
DR   Pfam; PF10463; Peptidase_U49; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Cell death peptidase"
FT                   /id="PRO_0000084446"
FT   TRANSMEM        61..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        121..135
FT                   /note="TGCESWPKKCPKPEA -> QVANHGLKNVPSQKH (in Ref. 1;
FT                   AAA24074)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   297 AA;  33762 MW;  8A06C0EB82FBB1AF CRC64;
     MRSPICHLFS AINSSPFKIA PEKEQDLKTI VDDKKIIISV VSEPGFNIRV RKNESNNSHE
     IVLTVASLEY IWAFSNFFWV FTQEYSKSQK NNDEHFDLTG KNRLKKSDEL LKWARKNLQT
     TGCESWPKKC PKPEAYLQGS EDSQVASEIF LCAIAWILHH EISHVVLQHP LVTTAFSTQE
     EREADSHATK WILGNLYESA PELKKRALGI ATAVLCIQSL EVENYFCLQN THPAAYERIY
     SNISCYPVGN EELIEALCTV MLQYLFHGKN INVNLDGESF SSILGDLLCD ISRLTSN