LIVG_ECOLI
ID LIVG_ECOLI Reviewed; 255 AA.
AC P0A9S7; P22730; Q2M7B8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=High-affinity branched-chain amino acid transport ATP-binding protein LivG;
DE AltName: Full=LIV-I protein G;
GN Name=livG; OrderedLocusNames=b3455, JW3420;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2195019; DOI=10.1016/s0021-9258(19)38417-0;
RA Adams M.D., Wagner L.M., Graddis T.J., Landick R., Antonucci T.K.,
RA Gibson A.L., Oxender D.L.;
RT "Nucleotide sequence and genetic characterization reveal six essential
RT genes for the LIV-I and LS transport systems of Escherichia coli.";
RL J. Biol. Chem. 265:11436-11443(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Component of the leucine-specific transport system.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; J05516; AAA83886.1; -; Genomic_DNA.
DR EMBL; U00039; AAB18430.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76480.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77838.1; -; Genomic_DNA.
DR PIR; F37074; F37074.
DR RefSeq; NP_417912.1; NC_000913.3.
DR RefSeq; WP_000082101.1; NZ_STEB01000004.1.
DR AlphaFoldDB; P0A9S7; -.
DR SMR; P0A9S7; -.
DR BioGRID; 4261119; 381.
DR ComplexPortal; CPX-4316; Branched chain amino acid ABC transporter complex.
DR ComplexPortal; CPX-4317; Branched chain amino acid, leucine-specific ABC transporter complex.
DR IntAct; P0A9S7; 6.
DR STRING; 511145.b3455; -.
DR TCDB; 3.A.1.4.1; the atp-binding cassette (abc) superfamily.
DR PaxDb; P0A9S7; -.
DR PRIDE; P0A9S7; -.
DR EnsemblBacteria; AAC76480; AAC76480; b3455.
DR EnsemblBacteria; BAE77838; BAE77838; BAE77838.
DR GeneID; 66672663; -.
DR GeneID; 947967; -.
DR KEGG; ecj:JW3420; -.
DR KEGG; eco:b3455; -.
DR PATRIC; fig|511145.12.peg.3553; -.
DR EchoBASE; EB0532; -.
DR eggNOG; COG0411; Bacteria.
DR HOGENOM; CLU_000604_1_2_6; -.
DR InParanoid; P0A9S7; -.
DR OMA; EHDMRFI; -.
DR PhylomeDB; P0A9S7; -.
DR BioCyc; EcoCyc:LIVG-MON; -.
DR BioCyc; MetaCyc:LIVG-MON; -.
DR PRO; PR:P0A9S7; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016020; C:membrane; IDA:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; ISM:EcoCyc.
DR GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0015188; F:L-isoleucine transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015192; F:L-phenylalanine transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0005304; F:L-valine transmembrane transporter activity; IDA:EcoCyc.
DR GO; GO:0015803; P:branched-chain amino acid transport; IDA:EcoCyc.
DR GO; GO:0042941; P:D-alanine transport; IBA:GO_Central.
DR GO; GO:1903714; P:isoleucine transmembrane transport; IDA:EcoCyc.
DR GO; GO:0015808; P:L-alanine transport; IBA:GO_Central.
DR GO; GO:1903806; P:L-isoleucine import across plasma membrane; IBA:GO_Central.
DR GO; GO:1903805; P:L-valine import across plasma membrane; IBA:GO_Central.
DR GO; GO:1903785; P:L-valine transmembrane transport; IDA:EcoCyc.
DR GO; GO:0098713; P:leucine import across plasma membrane; IBA:GO_Central.
DR GO; GO:0015823; P:phenylalanine transport; IDA:EcoCyc.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR032823; BCA_ABC_TP_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF12399; BCA_ABC_TP_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; ATP-binding; Nucleotide-binding; Reference proteome;
KW Transport.
FT CHAIN 1..255
FT /note="High-affinity branched-chain amino acid transport
FT ATP-binding protein LivG"
FT /id="PRO_0000092406"
FT DOMAIN 6..254
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 130
FT /note="A -> R (in Ref. 1; AAA83886)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="T -> S (in Ref. 1; AAA83886)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 255 AA; 28427 MW; D05B2F344DF7CA85 CRC64;
MSQPLLSVNG LMMRFGGLLA VNNVNLELYP QEIVSLIGPN GAGKTTVFNC LTGFYKPTGG
TILLRDQHLE GLPGQQIARM GVVRTFQHVR LFREMTVIEN LLVAQHQQLK TGLFSGLLKT
PSFRRAQSEA LDRAATWLER IGLLEHANRQ ASNLAYGDQR RLEIARCMVT QPEILMLDEP
AAGLNPKETK ELDELIAELR NHHNTTILLI EHDMKLVMGI SDRIYVVNQG TPLANGTPEQ
IRNNPDVIRA YLGEA
