LIVH_SALTY
ID LIVH_SALTY Reviewed; 308 AA.
AC P0A2J1; P30295;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=High-affinity branched-chain amino acid transport system permease protein LivH;
DE AltName: Full=LIV-I protein H;
GN Name=livH; Synonyms=livA; OrderedLocusNames=STM3563;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1429514; DOI=10.1093/oxfordjournals.jbchem.a123872;
RA Matsubara K., Ohnishi K., Kiritani K.;
RT "Nucleotide sequences and characterization of liv genes encoding components
RT of the high-affinity branched-chain amino acid transport system in
RT Salmonella typhimurium.";
RL J. Biochem. 112:93-101(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC branched-chain amino acids. Probably responsible for the translocation
CC of the substrates across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. LivHM subfamily. {ECO:0000305}.
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DR EMBL; D12589; BAA02129.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22423.1; -; Genomic_DNA.
DR PIR; JH0668; JH0668.
DR RefSeq; NP_462464.1; NC_003197.2.
DR RefSeq; WP_000003007.1; NC_003197.2.
DR AlphaFoldDB; P0A2J1; -.
DR STRING; 99287.STM3563; -.
DR PaxDb; P0A2J1; -.
DR EnsemblBacteria; AAL22423; AAL22423; STM3563.
DR GeneID; 1255086; -.
DR KEGG; stm:STM3563; -.
DR PATRIC; fig|99287.12.peg.3766; -.
DR HOGENOM; CLU_039929_3_1_6; -.
DR OMA; NMGWFLI; -.
DR PhylomeDB; P0A2J1; -.
DR BioCyc; SENT99287:STM3563-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015188; F:L-isoleucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015192; F:L-phenylalanine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005304; F:L-valine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042941; P:D-alanine transport; IBA:GO_Central.
DR GO; GO:0015808; P:L-alanine transport; IBA:GO_Central.
DR GO; GO:1903806; P:L-isoleucine import across plasma membrane; IBA:GO_Central.
DR GO; GO:1903785; P:L-valine transmembrane transport; IBA:GO_Central.
DR GO; GO:0098713; P:leucine import across plasma membrane; IBA:GO_Central.
DR GO; GO:0015823; P:phenylalanine transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..308
FT /note="High-affinity branched-chain amino acid transport
FT system permease protein LivH"
FT /id="PRO_0000060061"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..45
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..104
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..203
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..280
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 32990 MW; 1E177EF797D47330 CRC64;
MSEQFLYFLQ QMFNGVTLGS TYALIAIGYT MVYGIIGMIN FAHGEVYMIG SYVSFMIIAA
LMMMGIDTSW LLVAAGFIGA IIIASAYGWS IERVAYRPVR NSKRLIALIS AIGMSIFLQN
YVSLTEGSRD VALPSLFNGQ WIVGSSENFS ASITTMQAVI WIVTFLAMLA LTIFIRYSRM
GRACRACAED LKMASLLGIN TDRVIALTFV IGAAMAAVAG VLLGQFYGVI NPYIGFMAGM
KAFTAAVLGG IGSIPGAMIG GLILGVAEAL SSAYLSTEYK DVVSFALLIL VLLVMPTGIL
GRPEVEKV
