ID   LIVJ_ECO57              Reviewed;         367 AA.
AC   P0AD98; P02917; P76698; Q8CVL7; Q8X6S2;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Leu/Ile/Val-binding protein;
DE            Short=LIV-BP;
DE   Flags: Precursor;
GN   Name=livJ; OrderedLocusNames=Z4834, ECs4309;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: This protein is a component of the leucine, isoleucine,
CC       valine, (threonine) transport system, which is one of the two
CC       periplasmic binding protein-dependent transport systems of the high-
CC       affinity transport of the branched-chain amino acids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the leucine-binding protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG58569.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB37732.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG58569.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB37732.1; ALT_INIT; Genomic_DNA.
DR   PIR; E86013; E86013.
DR   PIR; E91167; E91167.
DR   RefSeq; NP_312336.1; NC_002695.1.
DR   RefSeq; WP_001021996.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AD98; -.
DR   SMR; P0AD98; -.
DR   STRING; 155864.EDL933_4673; -.
DR   EnsemblBacteria; AAG58569; AAG58569; Z4834.
DR   EnsemblBacteria; BAB37732; BAB37732; ECs_4309.
DR   GeneID; 66672656; -.
DR   GeneID; 915836; -.
DR   KEGG; ece:Z4834; -.
DR   KEGG; ecs:ECs_4309; -.
DR   PATRIC; fig|386585.9.peg.4502; -.
DR   eggNOG; COG0683; Bacteria.
DR   HOGENOM; CLU_027128_6_0_6; -.
DR   OMA; MEFTGAR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028081; Leu-bd.
DR   InterPro; IPR000709; Leu_Ile_Val-bd.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF13458; Peripla_BP_6; 1.
DR   PRINTS; PR00337; LEUILEVALBP.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Disulfide bond; Periplasm; Reference proteome;
KW   Signal; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..367
FT                   /note="Leu/Ile/Val-binding protein"
FT                   /id="PRO_0000043181"
FT   DISULFID        76..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   367 AA;  39076 MW;  63F0729C251F18FD CRC64;
     MNIKGKALLA GCIALAFSNM ALAEDIKVAV VGAMSGPVAQ YGDQEFTGAE QAVADINAKG
     GIKGNKLQIV KYDDACDPKQ AVAVANKVVN DGIKYVIGHL CSSSTQPASD IYEDEGILMI
     TPAATAPELT ARGYQLILRT TGLDSDQGPT AAKYILEKVK PQRIAIVHDK QQYGEGLARA
     VQDGLKKGNA NVVFFDGITA GEKDFSTLVA RLKKENIDFV YYGGYHPEMG QILRQARAAG
     LKTQFMGPEG VANVSLSNIA GESAEGLLVT KPKNYDQVPA NKPIVDAIKA KKQDPSGAFV
     WTTYAALQSL QAGLNQSDDP AEIAKYLKAN SVDTVMGPLT WDEKGDLKGF EFGVFDWHAN
     GTATDAK