ID   LIVJ_ECOL6              Reviewed;         367 AA.
AC   P0AD97; P02917; P76698; Q8CVL7; Q8X6S2;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Leu/Ile/Val-binding protein;
DE            Short=LIV-BP;
DE   Flags: Precursor;
GN   Name=livJ; OrderedLocusNames=c4253;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: This protein is a component of the leucine, isoleucine,
CC       valine, (threonine) transport system, which is one of the two
CC       periplasmic binding protein-dependent transport systems of the high-
CC       affinity transport of the branched-chain amino acids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the leucine-binding protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82689.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82689.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001021996.1; NC_004431.1.
DR   AlphaFoldDB; P0AD97; -.
DR   SMR; P0AD97; -.
DR   STRING; 199310.c4253; -.
DR   EnsemblBacteria; AAN82689; AAN82689; c4253.
DR   GeneID; 66672656; -.
DR   KEGG; ecc:c4253; -.
DR   eggNOG; COG0683; Bacteria.
DR   HOGENOM; CLU_027128_6_0_6; -.
DR   OMA; MEFTGAR; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028081; Leu-bd.
DR   InterPro; IPR000709; Leu_Ile_Val-bd.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF13458; Peripla_BP_6; 1.
DR   PRINTS; PR00337; LEUILEVALBP.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Disulfide bond; Periplasm; Signal; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..367
FT                   /note="Leu/Ile/Val-binding protein"
FT                   /id="PRO_0000043182"
FT   DISULFID        76..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   367 AA;  39076 MW;  63F0729C251F18FD CRC64;
     MNIKGKALLA GCIALAFSNM ALAEDIKVAV VGAMSGPVAQ YGDQEFTGAE QAVADINAKG
     GIKGNKLQIV KYDDACDPKQ AVAVANKVVN DGIKYVIGHL CSSSTQPASD IYEDEGILMI
     TPAATAPELT ARGYQLILRT TGLDSDQGPT AAKYILEKVK PQRIAIVHDK QQYGEGLARA
     VQDGLKKGNA NVVFFDGITA GEKDFSTLVA RLKKENIDFV YYGGYHPEMG QILRQARAAG
     LKTQFMGPEG VANVSLSNIA GESAEGLLVT KPKNYDQVPA NKPIVDAIKA KKQDPSGAFV
     WTTYAALQSL QAGLNQSDDP AEIAKYLKAN SVDTVMGPLT WDEKGDLKGF EFGVFDWHAN
     GTATDAK