ID   LIVK_SALTI              Reviewed;         369 AA.
AC   P0A1W7; P17216;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Leucine-specific-binding protein;
DE            Short=L-BP;
DE            Short=LS-BP;
DE   Flags: Precursor;
GN   Name=livK; Synonyms=livC; OrderedLocusNames=STY4248, t3958;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: This protein is a component of the leucine-specific transport
CC       system, which is one of the two periplasmic binding protein-dependent
CC       transport systems of the high-affinity transport of the branched-chain
CC       amino acids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the leucine-binding protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL513382; CAD08066.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71428.1; -; Genomic_DNA.
DR   RefSeq; NP_458356.1; NC_003198.1.
DR   RefSeq; WP_000822976.1; NZ_WSUR01000001.1.
DR   AlphaFoldDB; P0A1W7; -.
DR   SMR; P0A1W7; -.
DR   STRING; 220341.16505045; -.
DR   EnsemblBacteria; AAO71428; AAO71428; t3958.
DR   KEGG; stt:t3958; -.
DR   KEGG; sty:STY4248; -.
DR   PATRIC; fig|220341.7.peg.4338; -.
DR   eggNOG; COG0683; Bacteria.
DR   HOGENOM; CLU_027128_6_0_6; -.
DR   OMA; YGVGFEQ; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028081; Leu-bd.
DR   InterPro; IPR000709; Leu_Ile_Val-bd.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF13458; Peripla_BP_6; 1.
DR   PRINTS; PR00337; LEUILEVALBP.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Disulfide bond; Periplasm; Signal; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..369
FT                   /note="Leucine-specific-binding protein"
FT                   /id="PRO_0000017703"
FT   DISULFID        76..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   369 AA;  39401 MW;  752D7CC79369BBCA CRC64;
     MKRKAKTIIA GIVALAVSQG AMADDIKVAI VGAMSGPVAQ WGDMEFNGAR QAIKDINAKG
     GIKGDKLVGV EYDDACDPKQ AVAVANKIVN DGIQYVIGHL CSSSTQPASD IYEDEGILMI
     SPGATNPELT QRGYQYIMRT AGLDSSQGPT AAKYILETVK PQRIAIIHDK QQYGEGLARS
     VQDGLKQGNA NIVFFDGITA GEKDFSALIA RLQKENIDFV YYGGYYPEMG QMLRQARANG
     LKTQFMGPEG VGNASLSNIA GGAAEGMLVT MPKRYDQDPA NKAIVEALKA DKKDPSGPYV
     WITYAAVQSL ATAMTRSASH APLDLVKDLK ANGADTVIGP LKWDEKGDLK GFEFGVFQWH
     ADGSSTVAK