LIVK_SALTY
ID LIVK_SALTY Reviewed; 369 AA.
AC P0A1W6; P17216;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Leucine-specific-binding protein;
DE Short=L-BP;
DE Short=LS-BP;
DE Flags: Precursor;
GN Name=livK; Synonyms=livC; OrderedLocusNames=STM3564;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 25-40.
RC STRAIN=LT2;
RX PubMed=2193932; DOI=10.1093/oxfordjournals.jbchem.a123026;
RA Ohnishi K., Nakazima A., Matsubara K., Kiritani K.;
RT "Cloning and nucleotide sequences of livB and livC, the structural genes
RT encoding binding proteins of the high-affinity branched-chain amino acid
RT transport in Salmonella typhimurium.";
RL J. Biochem. 107:202-208(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: This protein is a component of the leucine-specific transport
CC system, which is one of the two periplasmic binding protein-dependent
CC transport systems of the high-affinity transport of the branched-chain
CC amino acids.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- SIMILARITY: Belongs to the leucine-binding protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D00478; BAA00370.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22424.1; -; Genomic_DNA.
DR PIR; JU0129; JU0129.
DR RefSeq; NP_462465.1; NC_003197.2.
DR RefSeq; WP_000822976.1; NC_003197.2.
DR AlphaFoldDB; P0A1W6; -.
DR SMR; P0A1W6; -.
DR STRING; 99287.STM3564; -.
DR PaxDb; P0A1W6; -.
DR EnsemblBacteria; AAL22424; AAL22424; STM3564.
DR GeneID; 1255087; -.
DR KEGG; stm:STM3564; -.
DR PATRIC; fig|99287.12.peg.3767; -.
DR HOGENOM; CLU_027128_6_0_6; -.
DR OMA; YGVGFEQ; -.
DR PhylomeDB; P0A1W6; -.
DR BioCyc; SENT99287:STM3564-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR000709; Leu_Ile_Val-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR PRINTS; PR00337; LEUILEVALBP.
DR SUPFAM; SSF53822; SSF53822; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Direct protein sequencing; Disulfide bond; Periplasm;
KW Reference proteome; Signal; Transport.
FT SIGNAL 1..23
FT CHAIN 24..369
FT /note="Leucine-specific-binding protein"
FT /id="PRO_0000017704"
FT DISULFID 76..101
FT /evidence="ECO:0000250"
FT CONFLICT 232..233
FT /note="ML -> IV (in Ref. 1; BAA00370)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="A -> R (in Ref. 1; BAA00370)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 39401 MW; 752D7CC79369BBCA CRC64;
MKRKAKTIIA GIVALAVSQG AMADDIKVAI VGAMSGPVAQ WGDMEFNGAR QAIKDINAKG
GIKGDKLVGV EYDDACDPKQ AVAVANKIVN DGIQYVIGHL CSSSTQPASD IYEDEGILMI
SPGATNPELT QRGYQYIMRT AGLDSSQGPT AAKYILETVK PQRIAIIHDK QQYGEGLARS
VQDGLKQGNA NIVFFDGITA GEKDFSALIA RLQKENIDFV YYGGYYPEMG QMLRQARANG
LKTQFMGPEG VGNASLSNIA GGAAEGMLVT MPKRYDQDPA NKAIVEALKA DKKDPSGPYV
WITYAAVQSL ATAMTRSASH APLDLVKDLK ANGADTVIGP LKWDEKGDLK GFEFGVFQWH
ADGSSTVAK
