ID   LIX1L_HUMAN             Reviewed;         337 AA.
AC   Q8IVB5; Q6AI36;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=LIX1-like protein;
GN   Name=LIX1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-337.
RC   TISSUE=Melanoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- SIMILARITY: Belongs to the LIX1 family. {ECO:0000305}.
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DR   EMBL; BC035727; AAH35727.1; -; mRNA.
DR   EMBL; CR627381; CAH10478.1; -; mRNA.
DR   CCDS; CCDS72873.1; -.
DR   RefSeq; NP_714924.1; NM_153713.2.
DR   AlphaFoldDB; Q8IVB5; -.
DR   BioGRID; 126092; 11.
DR   IntAct; Q8IVB5; 4.
DR   STRING; 9606.ENSP00000474487; -.
DR   iPTMnet; Q8IVB5; -.
DR   PhosphoSitePlus; Q8IVB5; -.
DR   BioMuta; LIX1L; -.
DR   DMDM; 74728055; -.
DR   EPD; Q8IVB5; -.
DR   jPOST; Q8IVB5; -.
DR   MassIVE; Q8IVB5; -.
DR   MaxQB; Q8IVB5; -.
DR   PaxDb; Q8IVB5; -.
DR   PeptideAtlas; Q8IVB5; -.
DR   PRIDE; Q8IVB5; -.
DR   ProteomicsDB; 70679; -.
DR   TopDownProteomics; Q8IVB5; -.
DR   Antibodypedia; 73360; 104 antibodies from 19 providers.
DR   DNASU; 128077; -.
DR   Ensembl; ENST00000604000.4; ENSP00000474487.3; ENSG00000271601.4.
DR   GeneID; 128077; -.
DR   KEGG; hsa:128077; -.
DR   MANE-Select; ENST00000604000.4; ENSP00000474487.3; NM_153713.3; NP_714924.1.
DR   UCSC; uc001enr.5; human.
DR   CTD; 128077; -.
DR   DisGeNET; 128077; -.
DR   GeneCards; LIX1L; -.
DR   HGNC; HGNC:28715; LIX1L.
DR   HPA; ENSG00000271601; Low tissue specificity.
DR   neXtProt; NX_Q8IVB5; -.
DR   OpenTargets; ENSG00000271601; -.
DR   PharmGKB; PA134915428; -.
DR   VEuPathDB; HostDB:ENSG00000271601; -.
DR   eggNOG; ENOG502QR91; Eukaryota.
DR   GeneTree; ENSGT00390000005869; -.
DR   HOGENOM; CLU_065651_0_1_1; -.
DR   InParanoid; Q8IVB5; -.
DR   OMA; XGNREEA; -.
DR   OrthoDB; 1026341at2759; -.
DR   PhylomeDB; Q8IVB5; -.
DR   TreeFam; TF324035; -.
DR   PathwayCommons; Q8IVB5; -.
DR   SignaLink; Q8IVB5; -.
DR   BioGRID-ORCS; 128077; 14 hits in 1069 CRISPR screens.
DR   ChiTaRS; LIX1L; human.
DR   GenomeRNAi; 128077; -.
DR   Pharos; Q8IVB5; Tdark.
DR   PRO; PR:Q8IVB5; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8IVB5; protein.
DR   Bgee; ENSG00000271601; Expressed in tibialis anterior and 188 other tissues.
DR   Genevisible; Q8IVB5; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR   InterPro; IPR029270; LIX1.
DR   Pfam; PF14954; LIX1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..337
FT                   /note="LIX1-like protein"
FT                   /id="PRO_0000232872"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..62
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  36563 MW;  0EC63B44AD5A744E CRC64;
     METMRAQRLQ PGVGTSGRGT LRALRPGVTG AAAATATPPA GPPPAPPPPA PPPPPLLLSG
     APGLPLPPGA AGSPAVLREA VEAVVRSFAK HTQGYGRVNV VEALQEFWQM KQSRGADLKN
     GALVVYEMVP SNSPPYVCYV TLPGGSCFGS FQFCPTKAEA RRSAAKIALM NSVFNEHPSR
     RITDEFIEKS VSEALASFNG NREEADNPNT GIGAFRFMLE SNKGKSMLEF QELMTVFQLL
     HWNGSLKAMR ERQCSRQEVL AHYSHRALDD DIRHQMALDW VSREQSVPGA LSRELASTER
     ELDEARLAGK ELRFHKEKKD ILVLAAGQLG NMHSSNC