LIX1_HUMAN
ID LIX1_HUMAN Reviewed; 282 AA.
AC Q8N485; A8K4R9; Q8N7I2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein limb expression 1 homolog;
GN Name=LIX1; Synonyms=C5orf11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-3.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N485; Q7Z589-5: EMSY; NbExp=3; IntAct=EBI-10694501, EBI-11989522;
CC Q8N485; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-10694501, EBI-1752811;
CC Q8N485; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-10694501, EBI-1055254;
CC Q8N485; Q96A04: TSACC; NbExp=3; IntAct=EBI-10694501, EBI-740411;
CC -!- SIMILARITY: Belongs to the LIX1 family. {ECO:0000305}.
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DR EMBL; AK098400; BAC05298.1; -; mRNA.
DR EMBL; AK291034; BAF83723.1; -; mRNA.
DR EMBL; CH471084; EAW96087.1; -; Genomic_DNA.
DR EMBL; BC036467; AAH36467.1; -; mRNA.
DR CCDS; CCDS4088.1; -.
DR RefSeq; NP_694966.3; NM_153234.4.
DR AlphaFoldDB; Q8N485; -.
DR BioGRID; 127946; 5.
DR IntAct; Q8N485; 6.
DR STRING; 9606.ENSP00000274382; -.
DR PhosphoSitePlus; Q8N485; -.
DR BioMuta; LIX1; -.
DR DMDM; 126302565; -.
DR PaxDb; Q8N485; -.
DR PeptideAtlas; Q8N485; -.
DR PRIDE; Q8N485; -.
DR ProteomicsDB; 71894; -.
DR Antibodypedia; 25115; 179 antibodies from 22 providers.
DR DNASU; 167410; -.
DR Ensembl; ENST00000274382.9; ENSP00000274382.4; ENSG00000145721.12.
DR GeneID; 167410; -.
DR KEGG; hsa:167410; -.
DR MANE-Select; ENST00000274382.9; ENSP00000274382.4; NM_153234.5; NP_694966.3.
DR UCSC; uc003kmy.5; human.
DR CTD; 167410; -.
DR DisGeNET; 167410; -.
DR GeneCards; LIX1; -.
DR HGNC; HGNC:18581; LIX1.
DR HPA; ENSG00000145721; Group enriched (brain, retina).
DR MIM; 610466; gene.
DR neXtProt; NX_Q8N485; -.
DR OpenTargets; ENSG00000145721; -.
DR PharmGKB; PA38353; -.
DR VEuPathDB; HostDB:ENSG00000145721; -.
DR eggNOG; ENOG502QR91; Eukaryota.
DR GeneTree; ENSGT00390000005869; -.
DR HOGENOM; CLU_065651_1_1_1; -.
DR InParanoid; Q8N485; -.
DR OMA; AMLQEFW; -.
DR OrthoDB; 1026341at2759; -.
DR PhylomeDB; Q8N485; -.
DR TreeFam; TF324035; -.
DR PathwayCommons; Q8N485; -.
DR SignaLink; Q8N485; -.
DR BioGRID-ORCS; 167410; 9 hits in 1063 CRISPR screens.
DR GenomeRNAi; 167410; -.
DR Pharos; Q8N485; Tbio.
DR PRO; PR:Q8N485; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N485; protein.
DR Bgee; ENSG00000145721; Expressed in lateral globus pallidus and 101 other tissues.
DR ExpressionAtlas; Q8N485; baseline and differential.
DR Genevisible; Q8N485; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR InterPro; IPR029270; LIX1.
DR Pfam; PF14954; LIX1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..282
FT /note="Protein limb expression 1 homolog"
FT /id="PRO_0000232869"
FT VARIANT 3
FT /note="R -> I (in dbSNP:rs11558079)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026039"
SQ SEQUENCE 282 AA; 31891 MW; B5642D1123C3CEF6 CRC64;
MDRTLESLRH IIAQVLPHRD PALVFKDLNV VSMLQEFWES KQQQKAAFPS EGVVVYESLP
APGPPFVSYV TLPGGSCFGN FQCCLSRAEA RRDAAKVALI NSLFNELPSR RITKEFIMES
VQEAVASTSG TLDDADDPST SVGAYHYMLE SNMGKTMLEF QELMTIFQLL HWNGSLKALR
ETKCSRQEVI SYYSQYSLDE KMRSHMALDW IMKERDSPGI VSQELRMALR QLEEARKAGQ
ELRFYKEKKE ILSLALTQIC SDPDTSSPSD DQLSLTALCG YH
