LIX1_MOUSE
ID LIX1_MOUSE Reviewed; 282 AA.
AC Q6P566; Q8VHY1; Q9CYH4;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein limb expression 1 homolog;
GN Name=Lix1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11731258; DOI=10.1016/s0925-4773(01)00535-4;
RA Swindell E.C., Moeller C., Thaller C., Eichele G.;
RT "Cloning and expression analysis of chicken Lix1, a founding member of a
RT novel gene family.";
RL Mech. Dev. 109:405-408(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the LIX1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30873.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF351204; AAL67190.1; -; mRNA.
DR EMBL; AK017685; BAB30873.1; ALT_FRAME; mRNA.
DR EMBL; BC063057; AAH63057.1; -; mRNA.
DR EMBL; BC049574; AAH49574.1; -; mRNA.
DR CCDS; CCDS37456.1; -.
DR RefSeq; NP_079957.2; NM_025681.2.
DR AlphaFoldDB; Q6P566; -.
DR STRING; 10090.ENSMUSP00000111239; -.
DR iPTMnet; Q6P566; -.
DR PhosphoSitePlus; Q6P566; -.
DR jPOST; Q6P566; -.
DR PaxDb; Q6P566; -.
DR PRIDE; Q6P566; -.
DR ProteomicsDB; 292266; -.
DR Antibodypedia; 25115; 179 antibodies from 22 providers.
DR DNASU; 66643; -.
DR Ensembl; ENSMUST00000115576; ENSMUSP00000111239; ENSMUSG00000047786.
DR GeneID; 66643; -.
DR KEGG; mmu:66643; -.
DR UCSC; uc008apg.2; mouse.
DR CTD; 167410; -.
DR MGI; MGI:1913893; Lix1.
DR VEuPathDB; HostDB:ENSMUSG00000047786; -.
DR eggNOG; ENOG502QR91; Eukaryota.
DR GeneTree; ENSGT00390000005869; -.
DR HOGENOM; CLU_065651_1_1_1; -.
DR InParanoid; Q6P566; -.
DR OMA; AMLQEFW; -.
DR OrthoDB; 1026341at2759; -.
DR PhylomeDB; Q6P566; -.
DR TreeFam; TF324035; -.
DR BioGRID-ORCS; 66643; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Lix1; mouse.
DR PRO; PR:Q6P566; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6P566; protein.
DR Bgee; ENSMUSG00000047786; Expressed in lens of camera-type eye and 123 other tissues.
DR ExpressionAtlas; Q6P566; baseline and differential.
DR Genevisible; Q6P566; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR InterPro; IPR029270; LIX1.
DR Pfam; PF14954; LIX1; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..282
FT /note="Protein limb expression 1 homolog"
FT /id="PRO_0000232870"
FT CONFLICT 199
FT /note="D -> G (in Ref. 1; AAL67190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 31915 MW; 7DC68D2E264255E7 CRC64;
MDRTLESLRH IIAQALPHRD PALVFKDLNV VSMLQEFWES KQQQKATFSS EGLVVYESMP
SSGPPFVSYV TLPGGSCFGN FQCCLSRAEA RRDAAKVALI NSLFNELPSR RITKEFIMES
VQEAVASTRG TLDDADDPST SVGAYHYMLE SNMGKTMLEF QELMTIFQLL HWNGSLKALR
ETKCSRQEVI SYYSQYSLDE KMRSHMALDW IMKERESPGI LSQELRAALG QLEEARKAGQ
ELRFYKEKKE ILSLALTQIY SDPDPSSPSD DQLSLTALCG YH
