LIZ1_SCHPO
ID LIZ1_SCHPO Reviewed; 514 AA.
AC O43000; P78874; Q1L845;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1999, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Pantothenate transporter liz1;
GN Name=liz1; ORFNames=SPBC2G2.01c, SPBC4B4.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RX PubMed=9950674; DOI=10.1091/mbc.10.2.245;
RA Moynihan E.B., Enoch T.;
RT "Liz1p, a novel fission yeast membrane protein, is required for normal cell
RT division when ribonucleotide reductase is inhibited.";
RL Mol. Biol. Cell 10:245-257(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-448.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15075270; DOI=10.1128/ec.3.2.406-412.2004;
RA Stolz J., Caspari T., Carr A.M., Sauer N.;
RT "Cell division defects of Schizosaccharomyces pombe liz1- mutants are
RT caused by defects in pantothenate uptake.";
RL Eukaryot. Cell 3:406-412(2004).
CC -!- FUNCTION: Transports pantothenate into the cell.
CC {ECO:0000269|PubMed:15075270}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15075270,
CC ECO:0000269|PubMed:9950674}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15075270, ECO:0000269|PubMed:9950674}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC permease family. {ECO:0000305}.
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DR EMBL; AF052688; AAC06236.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA19293.1; -; Genomic_DNA.
DR EMBL; D89224; BAA13885.1; -; mRNA.
DR PIR; T40485; T40485.
DR RefSeq; NP_596430.1; NM_001022349.2.
DR AlphaFoldDB; O43000; -.
DR SMR; O43000; -.
DR BioGRID; 276871; 66.
DR STRING; 4896.SPBC2G2.01c.1; -.
DR TCDB; 2.A.1.14.17; the major facilitator superfamily (mfs).
DR iPTMnet; O43000; -.
DR MaxQB; O43000; -.
DR PaxDb; O43000; -.
DR PRIDE; O43000; -.
DR EnsemblFungi; SPBC2G2.01c.1; SPBC2G2.01c.1:pep; SPBC2G2.01c.
DR PomBase; SPBC2G2.01c; liz1.
DR VEuPathDB; FungiDB:SPBC2G2.01c; -.
DR eggNOG; KOG2533; Eukaryota.
DR HOGENOM; CLU_001265_4_2_1; -.
DR InParanoid; O43000; -.
DR OMA; AWWPLVF; -.
DR PhylomeDB; O43000; -.
DR PRO; PR:O43000; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:PomBase.
DR GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0015233; F:pantothenate transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0098717; P:pantothenate import across plasma membrane; IMP:PomBase.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..514
FT /note="Pantothenate transporter liz1"
FT /id="PRO_0000121370"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 445..447
FT /note="IRD -> SAI (in Ref. 3; BAA13885)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 514 AA; 57964 MW; A4026A704EC1FECB CRC64;
MALLNRLAKT FSPYYGLNKV EQKLLIKIDW FILSYCCVSY FINYLDRSSI NNAYLSGMQE
DLKMHGNELQ DINVVFTCGY IIGQLPGSYA LQRVPARLWF SVMNILWGLM TIFSFAVHSV
RALMILRFFM AVAEASTFAG THYILGAWYK ESELCKRAGI FSASGLVGTM FAGYLQTAVH
SSLNGKGGLS GWRWLFIIDG ILTIPLSLYG LFLFPDVPET TKAPYFTEQE KELSFKRLPA
RPKKKPLTLK AIKDIVRSWR IYGLCILWIF SGETQAIAVN VLMGQWMKWS NKFSVAQINN
YPTVITAVGV VSTLGASVIS DKLAGNPRWP FGLFLCVITT VSATILLAWN VPDGAKFFAY
FASGCTYAGQ AVWFSWANDI CRDNDQERGV VVFLMNMCQN IWHIWWAPIM YPNTDTPRFI
KGLIGLLVVG GIVFVSSCIV SYMQIRDKRI KRSIQDAKDF DDVFTEHESL ELKKIGKNDE
ESLNTTNAVK EISSPGLVIT RQRISMPKET NAQD
