LJ01_HUMAN
ID LJ01_HUMAN Reviewed; 42 AA.
AC A0A0A0MT76;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 07-JAN-2015, sequence version 1.
DT 03-AUG-2022, entry version 33.
DE RecName: Full=Immunoglobulin lambda joining 1 {ECO:0000303|PubMed:11872955, ECO:0000303|Ref.3};
GN Name=IGLJ1 {ECO:0000303|PubMed:11872955, ECO:0000303|Ref.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE IGLJ1*01).
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NOMENCLATURE.
RX PubMed=11872955; DOI=10.1159/000049203;
RA Lefranc M.P.;
RT "Nomenclature of the human immunoglobulin lambda (IGL) genes.";
RL Exp. Clin. Immunogenet. 18:242-254(2001).
RN [3]
RP NOMENCLATURE.
RA Lefranc M.P., Lefranc G.;
RT "The Immunoglobulin FactsBook.";
RL (In) Lefranc M.P., Lefranc G. (eds.);
RL The Immunoglobulin FactsBook., pp.1-458, Academic Press, London. (2001).
RN [4]
RP REVIEW ON SOMATIC HYPERMUTATION.
RX PubMed=17576170; DOI=10.1146/annurev.genet.41.110306.130340;
RA Teng G., Papavasiliou F.N.;
RT "Immunoglobulin somatic hypermutation.";
RL Annu. Rev. Genet. 41:107-120(2007).
RN [5]
RP REVIEW ON IMMUNOGLOBULINS.
RX PubMed=20176268; DOI=10.1016/j.jaci.2009.09.046;
RA Schroeder H.W. Jr., Cavacini L.;
RT "Structure and function of immunoglobulins.";
RL J. Allergy Clin. Immunol. 125:S41-S52(2010).
RN [6]
RP REVIEW ON FUNCTION.
RX PubMed=22158414; DOI=10.1038/nri3128;
RA McHeyzer-Williams M., Okitsu S., Wang N., McHeyzer-Williams L.;
RT "Molecular programming of B cell memory.";
RL Nat. Rev. Immunol. 12:24-34(2012).
RN [7]
RP NOMENCLATURE.
RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA Lefranc M.P.;
RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT of Immunoinformatics.";
RL Front. Immunol. 5:22-22(2014).
CC -!- FUNCTION: J region of the variable domain of immunoglobulin lambda
CC light chains that participates in the antigen recognition
CC (PubMed:24600447). Immunoglobulins, also known as antibodies, are
CC membrane-bound or secreted glycoproteins produced by B lymphocytes. In
CC the recognition phase of humoral immunity, the membrane-bound
CC immunoglobulins serve as receptors which, upon binding of a specific
CC antigen, trigger the clonal expansion and differentiation of B
CC lymphocytes into immunoglobulins-secreting plasma cells. Secreted
CC immunoglobulins mediate the effector phase of humoral immunity, which
CC results in the elimination of bound antigens (PubMed:22158414,
CC PubMed:20176268). The antigen binding site is formed by the variable
CC domain of one heavy chain, together with that of its associated light
CC chain. Thus, each immunoglobulin has two antigen binding sites with
CC remarkable affinity for a particular antigen. The variable domains are
CC assembled by a process called V-(D)-J rearrangement and can then be
CC subjected to somatic hypermutations which, after exposure to antigen
CC and selection, allow affinity maturation for a particular antigen
CC (PubMed:20176268, PubMed:17576170). {ECO:0000303|PubMed:17576170,
CC ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414,
CC ECO:0000303|PubMed:24600447}.
CC -!- SUBUNIT: Immunoglobulins are composed of two identical heavy chains and
CC two identical light chains; disulfide-linked.
CC {ECO:0000303|PubMed:20176268}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268,
CC ECO:0000303|PubMed:22158414}. Cell membrane
CC {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
CC -!- POLYMORPHISM: The sequence shown is that of IMGT allele IGLJ1*01.
CC {ECO:0000305}.
CC -!- CAUTION: There are several genes encoding the J region in the
CC immunoglobulin lambda locus. The peptide described in this entry is a
CC representative for all the peptides encoded by these genes. For an
CC example of a full-length immunoglobulin lambda light chain see AC
CC P0DOX8. {ECO:0000305}.
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DR EMBL; AC245028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0A0MT76; -.
DR SMR; A0A0A0MT76; -.
DR IMGT_GENE-DB; IGLJ1; -.
DR BioMuta; IGLJ1; -.
DR MassIVE; A0A0A0MT76; -.
DR PeptideAtlas; A0A0A0MT76; -.
DR Ensembl; ENST00000390320.2; ENSP00000417505.1; ENSG00000211674.2.
DR UCSC; uc062cdx.1; human.
DR GeneCards; IGLJ1; -.
DR HGNC; HGNC:5863; IGLJ1.
DR HPA; ENSG00000211674; Group enriched (intestine, lymphoid tissue, salivary gland, stomach).
DR neXtProt; NX_A0A0A0MT76; -.
DR OpenTargets; ENSG00000211674; -.
DR VEuPathDB; HostDB:ENSG00000211674; -.
DR HOGENOM; CLU_3263083_0_0_1; -.
DR Pharos; A0A0A0MT76; Tdark.
DR PRO; PR:A0A0A0MT76; -.
DR Proteomes; UP000005640; Chromosome 22.
DR Bgee; ENSG00000211674; Expressed in duodenum and 82 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
PE 4: Predicted;
KW Adaptive immunity; Cell membrane; Immunity; Immunoglobulin; Membrane;
KW Reference proteome; Secreted.
FT CHAIN <1..>42
FT /note="Immunoglobulin lambda joining 1"
FT /id="PRO_0000439094"
FT NON_TER 1
FT NON_TER 42
SQ SEQUENCE 42 AA; 4776 MW; 345BE3BC28CBB12E CRC64;
PSRLLLQPSP QRADPRCWPR GFWSEPQSLC YVFGTGTKVT VL
