LKAM1_MOUSE
ID LKAM1_MOUSE Reviewed; 198 AA.
AC Q8BIG2; Q5I0W3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein LKAAEAR1;
DE AltName: Full=LKAAEAR motif-containing protein 1;
GN Name=Lkaaear1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK076877; BAC36518.1; -; mRNA.
DR EMBL; AL845173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC087873; AAH87873.1; -; mRNA.
DR CCDS; CCDS17221.1; -.
DR RefSeq; NP_950188.2; NM_199023.3.
DR AlphaFoldDB; Q8BIG2; -.
DR SMR; Q8BIG2; -.
DR STRING; 10090.ENSMUSP00000061134; -.
DR PhosphoSitePlus; Q8BIG2; -.
DR EPD; Q8BIG2; -.
DR PaxDb; Q8BIG2; -.
DR PRIDE; Q8BIG2; -.
DR ProteomicsDB; 290131; -.
DR Antibodypedia; 44636; 72 antibodies from 12 providers.
DR Ensembl; ENSMUST00000052416; ENSMUSP00000061134; ENSMUSG00000045794.
DR GeneID; 277496; -.
DR KEGG; mmu:277496; -.
DR UCSC; uc008onh.1; mouse.
DR CTD; 198437; -.
DR MGI; MGI:2685538; Lkaaear1.
DR VEuPathDB; HostDB:ENSMUSG00000045794; -.
DR eggNOG; ENOG502S5XG; Eukaryota.
DR GeneTree; ENSGT00390000009883; -.
DR HOGENOM; CLU_092463_0_0_1; -.
DR InParanoid; Q8BIG2; -.
DR OMA; ERGWQHL; -.
DR OrthoDB; 1320680at2759; -.
DR PhylomeDB; Q8BIG2; -.
DR TreeFam; TF337699; -.
DR BioGRID-ORCS; 277496; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BIG2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BIG2; protein.
DR Bgee; ENSMUSG00000045794; Expressed in seminiferous tubule of testis and 6 other tissues.
DR ExpressionAtlas; Q8BIG2; baseline and differential.
DR Genevisible; Q8BIG2; MM.
DR InterPro; IPR029152; LKAAEAR1.
DR PANTHER; PTHR35665; PTHR35665; 1.
DR Pfam; PF15478; LKAAEAR; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..198
FT /note="Protein LKAAEAR1"
FT /id="PRO_0000329280"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 189
FT /note="E -> K (in Ref. 1; BAC36518)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 198 AA; 22126 MW; 830EBDE618E22C8C CRC64;
MPTLGVKGAR ERDKNSASGA GAGAGAGAGA GEKHRKGPRT TDPPKTGWAL TKQRLVALSP
TLRQRHLLFG DFLDDIGKVA SMFPRESVEL PYDMPDPRTW SQALNLPSEH QNRFLGLIKA
AEARGRVHTL RLRYTRMRAE EISLLIQKQS SARAAIRLEL FLPPQLKPTK IPDPLDRHER
RRVETILEEE VDGNIFPR
